Open Access

Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report

  • Authors:
    • Lianghua Fang
    • Yue Hu
    • Wei Wang
    • Shouyou Hu
    • Li Zhang
    • Ruiping Wang
  • View Affiliations

  • Published online on: April 7, 2016     https://doi.org/10.3892/mco.2016.854
  • Pages: 929-932
  • Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Leukocytoclastic vasculitis (LCV) is a neutrophilic inflammation of the blood vessels. LCV may present as a paraneoplastic syndrome occurring before, synchronously with, or after the diagnosis of malignancy. In this study, we report a unique case of multiple malignancies developing simultaneously in a patient with a long history of LCV. The patient was originally diagnosed with LCV and received long‑term glucocorticoid treatment. After 11 years of therapy, the patient developed three primary malignancies, including small‑cell lung carcinoma, gastric adenocarcinoma and colonic adenocarcinoma. It is likely that LCV was not a paraneoplastic syndrome in this case, but rather an independent process, and the development of multiple cancers is likely associated with the long‑term glucocorticoid treatment, which caused imbalance of the immune system. Although the development of cancer during the course of glucocorticoid treatment is very rare, clinicians must be aware of this possible association and immunodysregulation may play a role in this context.
View Figures
View References

Related Articles

Journal Cover

June 2016
Volume 4 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Fang, L., Hu, Y., Wang, W., Hu, S., Zhang, L., & Wang, R. (2016). Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report. Molecular and Clinical Oncology, 4, 929-932. https://doi.org/10.3892/mco.2016.854
MLA
Fang, L., Hu, Y., Wang, W., Hu, S., Zhang, L., Wang, R."Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report". Molecular and Clinical Oncology 4.6 (2016): 929-932.
Chicago
Fang, L., Hu, Y., Wang, W., Hu, S., Zhang, L., Wang, R."Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report". Molecular and Clinical Oncology 4, no. 6 (2016): 929-932. https://doi.org/10.3892/mco.2016.854