Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences

  • Authors:
    • Edyta Wolny‑Rokicka
    • Krzysztof Sutkowski
    • Aleksandra Grządziel
    • Żaneta Dorsz
    • Andrzej Tukiendorf
    • Jakub Lipiński
    • Jerzy Wydmański
  • View Affiliations

  • Published online on: April 7, 2016     https://doi.org/10.3892/mco.2016.851
  • Pages: 1088-1092
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Abstract

This study was conducted to investigate hypofractionated radiotherapy (RT) in patients with locally advanced or metastatic adenocarcinoma of the pancreas. A total of 31 patients were enrolled in this study, 26 of whom had locally advanced (M0) pancreatic cancer and 5 had metastatic (M1) disease. The patients were treated with palliative RT (6‑30 Gy in 1‑10 fractions over a period of 1 day‑2 weeks). Treatment‑related toxicity was classified according to the Common Terminology Criteria for Adverse Events, version 3.0. Early mild toxicity was observed. A total of 17 patients (55%) achieved good pain control without pharmacological therapy, and 12 patients (39%) reduced their use of analgesics; in the remaining 2 patients (6%), there was no change in analgesic use. Late high‑grade (>3) toxicity was not observed. The average survival time for the 31 patients was 9 months. The 1‑year overall survival rate was 16%. Palliative RT was well-tolerated and was able to prolong the survival time. The majority of the patients achieved better pain control with palliative RT.
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June-2016
Volume 4 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Wolny‑Rokicka, E., Sutkowski, K., Grządziel, A., Dorsz, Ż., Tukiendorf, A., Lipiński, J., & Wydmański, J. (2016). Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences. Molecular and Clinical Oncology, 4, 1088-1092. https://doi.org/10.3892/mco.2016.851
MLA
Wolny‑Rokicka, E., Sutkowski, K., Grządziel, A., Dorsz, Ż., Tukiendorf, A., Lipiński, J., Wydmański, J."Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences". Molecular and Clinical Oncology 4.6 (2016): 1088-1092.
Chicago
Wolny‑Rokicka, E., Sutkowski, K., Grządziel, A., Dorsz, Ż., Tukiendorf, A., Lipiński, J., Wydmański, J."Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences". Molecular and Clinical Oncology 4, no. 6 (2016): 1088-1092. https://doi.org/10.3892/mco.2016.851