Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences

  • Authors:
    • Edyta Wolny‑Rokicka
    • Krzysztof Sutkowski
    • Aleksandra Grządziel
    • Żaneta Dorsz
    • Andrzej Tukiendorf
    • Jakub Lipiński
    • Jerzy Wydmański
  • View Affiliations

  • Published online on: April 7, 2016     https://doi.org/10.3892/mco.2016.851
  • Pages: 1088-1092
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study was conducted to investigate hypofractionated radiotherapy (RT) in patients with locally advanced or metastatic adenocarcinoma of the pancreas. A total of 31 patients were enrolled in this study, 26 of whom had locally advanced (M0) pancreatic cancer and 5 had metastatic (M1) disease. The patients were treated with palliative RT (6‑30 Gy in 1‑10 fractions over a period of 1 day‑2 weeks). Treatment‑related toxicity was classified according to the Common Terminology Criteria for Adverse Events, version 3.0. Early mild toxicity was observed. A total of 17 patients (55%) achieved good pain control without pharmacological therapy, and 12 patients (39%) reduced their use of analgesics; in the remaining 2 patients (6%), there was no change in analgesic use. Late high‑grade (>3) toxicity was not observed. The average survival time for the 31 patients was 9 months. The 1‑year overall survival rate was 16%. Palliative RT was well-tolerated and was able to prolong the survival time. The majority of the patients achieved better pain control with palliative RT.
View Figures
View References

Related Articles

Journal Cover

June 2016
Volume 4 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wolny‑Rokicka, E., Sutkowski, K., Grządziel, A., Dorsz, Ż., Tukiendorf, A., Lipiński, J., & Wydmański, J. (2016). Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences. Molecular and Clinical Oncology, 4, 1088-1092. https://doi.org/10.3892/mco.2016.851
MLA
Wolny‑Rokicka, E., Sutkowski, K., Grządziel, A., Dorsz, Ż., Tukiendorf, A., Lipiński, J., Wydmański, J."Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences". Molecular and Clinical Oncology 4.6 (2016): 1088-1092.
Chicago
Wolny‑Rokicka, E., Sutkowski, K., Grządziel, A., Dorsz, Ż., Tukiendorf, A., Lipiński, J., Wydmański, J."Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single‑institutional experiences". Molecular and Clinical Oncology 4, no. 6 (2016): 1088-1092. https://doi.org/10.3892/mco.2016.851