Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies

  • Authors:
    • Ming‑Xing Zhang
    • Kai Liu
    • Fu‑Gang Wang
    • Xiao‑Wen Wen
    • Xi‑Lin Song
  • View Affiliations

  • Published online on: March 18, 2016     https://doi.org/10.3892/mco.2016.824
  • Pages: 1031-1038
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Abstract

Previous studies suggested that RsaI/PstI and DraI polymorphisms on cytochrome P450 2E1 (CYP2E1) may be associated with susceptibility to gastric cancer (GC). However, this association remains ambiguous. A meta‑analysis of previously published studies was performed in an attempt to elucidate this association. The odds ratio and 95% confidence interval were used to assess the strength of the association. In the overall analyses of RsaI/PstI and DraI, no association was identified. In the subgroup analyses, RsaI/PstI was identified to increase the risk of GC in the smoking population. In addition, in the previous studies of interactions with other genes, RsaI/PstI was revealed to be associated with increased GC risks when glutathione S‑transferase‑µ‑1 or glutathione S‑transferase θ‑1 was null or DraI was homozygous wild‑type. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers. In conclusion, CYP2E1 polymorphisms revealed no association with the risk of GC.
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June 2016
Volume 4 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Zhang, M., Liu, K., Wang, F., Wen, X., & Song, X. (2016). Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies. Molecular and Clinical Oncology, 4, 1031-1038. https://doi.org/10.3892/mco.2016.824
MLA
Zhang, M., Liu, K., Wang, F., Wen, X., Song, X."Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies". Molecular and Clinical Oncology 4.6 (2016): 1031-1038.
Chicago
Zhang, M., Liu, K., Wang, F., Wen, X., Song, X."Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies". Molecular and Clinical Oncology 4, no. 6 (2016): 1031-1038. https://doi.org/10.3892/mco.2016.824