Efficacy of weekly paclitaxel treatment as a single agent chemotherapy following first-line cisplatin treatment in urothelial bladder cancer

  • Authors:
    • Spyridon Sideris
    • Fouad Aoun
    • Marc Zanaty
    • Nieves Chanza Martinez
    • Sofia Latifyan
    • Ahmad Awada
    • Thierry Gil
  • View Affiliations

  • Published online on: March 17, 2016     https://doi.org/10.3892/mco.2016.821
  • Pages: 1063-1067
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Abstract

The aim of the present study was to investigate the efficacy of paclitaxel following a first-line cisplatin regimen in patients with metastatic bladder cancer. The present study retrospectively evaluated the clinical effects and toxicities of second-line paclitaxel regimens following first-line cisplatin treatment in metastatic bladder cancer. A total of 42 patients with progressing metastatic urothelial bladder cancer following cisplatin-based chemotherapy were enrolled. The patients received weekly treatment with paclitaxel (80 mg/m2) with a median duration of 3 months. The overall response rate, disease control rate and median progression free survival were 9.5, 45.2 and 6.4 months, respectively. Weekly paclitaxel was well-tolerated with rare grade III or IV toxicities. Second-line weekly paclitaxel treatment following first-line cisplatin-based chemotherapy is an effective and well-tolerated regimen in urothelial metastatic bladder cancer.
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June 2016
Volume 4 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Sideris, S., Aoun, F., Zanaty, M., Martinez, N.C., Latifyan, S., Awada, A., & Gil, T. (2016). Efficacy of weekly paclitaxel treatment as a single agent chemotherapy following first-line cisplatin treatment in urothelial bladder cancer. Molecular and Clinical Oncology, 4, 1063-1067. https://doi.org/10.3892/mco.2016.821
MLA
Sideris, S., Aoun, F., Zanaty, M., Martinez, N. C., Latifyan, S., Awada, A., Gil, T."Efficacy of weekly paclitaxel treatment as a single agent chemotherapy following first-line cisplatin treatment in urothelial bladder cancer". Molecular and Clinical Oncology 4.6 (2016): 1063-1067.
Chicago
Sideris, S., Aoun, F., Zanaty, M., Martinez, N. C., Latifyan, S., Awada, A., Gil, T."Efficacy of weekly paclitaxel treatment as a single agent chemotherapy following first-line cisplatin treatment in urothelial bladder cancer". Molecular and Clinical Oncology 4, no. 6 (2016): 1063-1067. https://doi.org/10.3892/mco.2016.821