Open Access

Outcome of patients with glioblastoma in Saudi Arabia: Single center experience

  • Authors:
    • Abdullah K. Altwairgi
    • Waleed Algareeb
    • Gaaem Yahya
    • Ahmed M. Maklad
    • Moamen Mom Aly
    • Wafa Al Shakweer
    • Ali Balbaid
    • Eyad Alsaeed
    • Hussain Alhussain
    • Yassir Orz
    • Ahmed Lary
    • Ashraf Elyamany
  • View Affiliations

  • Published online on: March 10, 2016     https://doi.org/10.3892/mco.2016.818
  • Pages: 756-762
  • Copyright: © Altwairgi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma multiforme (GBM), the most common primary brain tumor in adults, is associated with one of the worst 5 year survival rates among all human cancer types. To date, no published data are available for the outcome of this disease in Saudi Arabia. The present study performed a single‑center, retrospective cohort study to evaluate the outcome of patients with GBM in Saudi Arabia. The Comprehensive Cancer Center at King Fahad Medical city (Riyadh, Saudi Arabia) was used in the present study. All adult patients (≥18 years) diagnosed with histologically proven GBM between January 2008 and December 2013 were included in the present study. A total of 90 patients were treated during the specified period. Of this, 73 (81%) patients underwent resection and 17 (19%) had biopsy only. The majority of patients (n=88; 98%) received radiotherapy (XRT): 67 (76%) with standard and 21 (24%) with hypo‑fractionated dosage. Of the total patients, 65 (72%) received combined modality therapy [standard XRT concurrently with Temozolmide (TMZ)]. The 6 month progression‑free survival rate was 43% for all patients and 55% for the combined modality subgroup. The median overall survival (OS) for all patients was 13.7 months. However, the median OS for patients treated with combined modality was 19.7 months. In this single‑center retrospective study, the outcomes of patients with GBM were similar to those in previously reported studies. An improved outcome was associated with an improved performance status, absence of residual disease and use of adjuvant TMZ.
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May 2016
Volume 4 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Altwairgi, A.K., Algareeb, W., Yahya, G., Maklad, A.M., Aly, M.M., Al Shakweer, W. ... Elyamany, A. (2016). Outcome of patients with glioblastoma in Saudi Arabia: Single center experience. Molecular and Clinical Oncology, 4, 756-762. https://doi.org/10.3892/mco.2016.818
MLA
Altwairgi, A. K., Algareeb, W., Yahya, G., Maklad, A. M., Aly, M. M., Al Shakweer, W., Balbaid, A., Alsaeed, E., Alhussain, H., Orz, Y., Lary, A., Elyamany, A."Outcome of patients with glioblastoma in Saudi Arabia: Single center experience". Molecular and Clinical Oncology 4.5 (2016): 756-762.
Chicago
Altwairgi, A. K., Algareeb, W., Yahya, G., Maklad, A. M., Aly, M. M., Al Shakweer, W., Balbaid, A., Alsaeed, E., Alhussain, H., Orz, Y., Lary, A., Elyamany, A."Outcome of patients with glioblastoma in Saudi Arabia: Single center experience". Molecular and Clinical Oncology 4, no. 5 (2016): 756-762. https://doi.org/10.3892/mco.2016.818