Effect of oncological treatment on serum adipocytokine levels in patients with stage II-III breast cancer

  • Authors:
    • Teoman Coskun
    • Funda Kosova
    • Zeki Ari
    • Aslan Sakarya
    • Yavuz Kaya
  • View Affiliations

  • Published online on: March 10, 2016     https://doi.org/10.3892/mco.2016.815
  • Pages: 893-897
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Adipose tissue-derived hormones (adipocytokines), such as adiponectin, leptin, resistin and visfatin, and the pancreatic hormone insulin, have been suggested to play a role in carcinogenesis. we therefore hypothesized that the oncological treatment of breast cancer may alter the serum levels of these adipocytokines and insulin. In this study, we aimed to compare the serum levels of adipocytokines and insulin between the pre‑ and post-treatment period in patients with breast cancer. In this prospective study, 20 consecutive patients with stage II and III breast cancer underwent breast‑conserving surgery or total mastectomy and/or axillary dissection. The patients received adjuvant chemotherapy and radiotherapy, if necessary. Blood samples were obtained during the preoperative period and postoperatively after completion of the adjuvant therapy. There was no statistically significant difference between the pre- and post-treatment levels of visfatin, adiponectin and leptin. However, the serum insulin and resistin levels and insulin resistance were found to be statistically significantly increased following treatment (P<0.05). Post-treatment resistin levels were positively correlated with insulin resistance (r=0.45, P<0.05). Therefore, oncological treatment of stage II and III breast cancer did not affect visfatin, adiponectin and leptin levels, but statistically significantly increased resistin levels and insulin resistance. In addition, the post‑treatment resistin levels were positively correlated with insulin resistance, suggesting that resistin may be involved in the development of insulin resistance in breast cancer patients following treatment.
View Figures
View References

Related Articles

Journal Cover

May 2016
Volume 4 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Coskun, T., Kosova, F., Ari, Z., Sakarya, A., & Kaya, Y. (2016). Effect of oncological treatment on serum adipocytokine levels in patients with stage II-III breast cancer. Molecular and Clinical Oncology, 4, 893-897. https://doi.org/10.3892/mco.2016.815
MLA
Coskun, T., Kosova, F., Ari, Z., Sakarya, A., Kaya, Y."Effect of oncological treatment on serum adipocytokine levels in patients with stage II-III breast cancer". Molecular and Clinical Oncology 4.5 (2016): 893-897.
Chicago
Coskun, T., Kosova, F., Ari, Z., Sakarya, A., Kaya, Y."Effect of oncological treatment on serum adipocytokine levels in patients with stage II-III breast cancer". Molecular and Clinical Oncology 4, no. 5 (2016): 893-897. https://doi.org/10.3892/mco.2016.815