Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls

  • Authors:
    • Xiangsheng Wang
    • Tong Luo
    • Mingjun Ruan
    • Pan Liu
    • Shiying Wang
    • Wenhao Zhu
  • View Affiliations

  • Published online on: March 9, 2016     https://doi.org/10.3892/mco.2016.813
  • Pages: 878-882
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Abstract

Published data on the association between the coiled‑coil domain‑containing 26 (CCDC26) rs4295627 polymorphism and the risk of glioma have been inconclusive. To further investigate this association, a meta‑analysis was performed. By a comprehensive literature search using PubMed and EMBASE databases, a total of 16 case‑control studies were identified for inclusion in the meta‑analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess this association. Our results confirmed that the risk with allele G was higher compared with that with allele T for glioma. The results indicated that the allele G of rs4295627 polymorphism in the CCDC26 gene was associated with increased risk of glioma in the homozygote model (GG vs. TT, OR=1.936, 95 %CI: 1.500‑2.658, P<0.001), the heterozygote model (GT vs. TT, OR=1.323, 95% CI: 1.241‑1.412, P=0.206), the dominant model (GG+GT vs. TT, OR=1.375, 95% CI: 1.256‑1.505, P=0.026), the recessive model (GG vs. GT+TT, OR=1.769, 95% CI: 1.302‑2.403, P<0.001) and the allele model (G vs. T, OR=1.310, 95% CI: 1.185‑1.448, P<0.001). Current evidence suggests that the rs4295627 polymorphism in the CCDC26 gene may contribute to glioma susceptibility. However, further case‑control studies are required to confirm our results.
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May 2016
Volume 4 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Wang, X., Luo, T., Ruan, M., Liu, P., Wang, S., & Zhu, W. (2016). Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls. Molecular and Clinical Oncology, 4, 878-882. https://doi.org/10.3892/mco.2016.813
MLA
Wang, X., Luo, T., Ruan, M., Liu, P., Wang, S., Zhu, W."Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls". Molecular and Clinical Oncology 4.5 (2016): 878-882.
Chicago
Wang, X., Luo, T., Ruan, M., Liu, P., Wang, S., Zhu, W."Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls". Molecular and Clinical Oncology 4, no. 5 (2016): 878-882. https://doi.org/10.3892/mco.2016.813