Open Access

Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report

  • Authors:
    • Hiroshi Shima
    • Hiroaki Ozasa
    • Takahiro Tsuji
    • Hitomi Ajimizu
    • Takashi Nomizo
    • Yoshitaka Yagi
    • Yuichi Sakamori
    • Hiroki Nagai
    • Sachiko Minamiguchi
    • Young Hak Kim
    • Michiaki Mishima
  • View Affiliations

  • Published online on: March 7, 2016     https://doi.org/10.3892/mco.2016.803
  • Pages: 715-718
  • Copyright: © Shima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thymic carcinoma is a rare neoplasm with a poor outcome due to its aggressive characteristics. For patients who are not operable, radiation therapy and/or palliative chemotherapy are indicated. However, no optimal chemotherapy regimen has been established. The present study reports the case of a 22‑year‑old man with advanced lymphoepithelioma‑like thymic carcinoma refractory to conventional chemotherapy with carboplatin plus solvent‑based paclitaxel (sb‑PAC) treatment. The patient was subsequently treated with carboplatin plus nanoparticle albumin‑bound paclitaxel (nab‑PAC). The treatment resulted in a partial response following three cycles of chemotherapy. Since only grade 3 neutropenia, but no other severe adverse effects, was observed, no dose reduction was required. To the best of our knowledge, the current study is the first to present the response to chemotherapy with carboplatin plus nab‑PAC in a patient with lymphoepithelioma‑like thymic carcinoma. Considering that no standard treatment has been established in thymic carcinoma, nab‑PAC may merit further investigation in this rare, but aggressive disease.
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May 2016
Volume 4 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y. ... Mishima, M. (2016). Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report. Molecular and Clinical Oncology, 4, 715-718. https://doi.org/10.3892/mco.2016.803
MLA
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y., Sakamori, Y., Nagai, H., Minamiguchi, S., Kim, Y. H., Mishima, M."Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report". Molecular and Clinical Oncology 4.5 (2016): 715-718.
Chicago
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y., Sakamori, Y., Nagai, H., Minamiguchi, S., Kim, Y. H., Mishima, M."Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report". Molecular and Clinical Oncology 4, no. 5 (2016): 715-718. https://doi.org/10.3892/mco.2016.803