A rare case of tumor-mimicking primary angiitis of the central nervous system
- Authors:
- Li Sun
- Lijun Zhu
- Teng Zhao
- Dayan Wang
- Dihui Ma
- Rensheng Zhang
- Shaokuan Fang
View Affiliations
Affiliations: Department of Neurology, The First Teaching Hospital of The Jilin University, Changchun, Jilin 130021, P.R. China, Department of Neurology, The Third Teaching Hospital of The Jilin University, Changchun, Jilin 130033, P.R. China, Qian Wei Hospital of Jilin Province, Changchun, Jilin 130031, P.R. China
-
Published online on: February 18, 2016
https://doi.org/10.3892/mco.2016.784
-
Pages: 827-829
Metrics:
Total Views:
0
(Spandidos Publications:
| PMC Statistics:
)
Metrics:
Total PDF Downloads:
0
(Spandidos Publications:
| PMC Statistics:
)
This article is mentioned in:
Abstract
Primary angiitis of the central nervous system (PACNS) is a rare, but severe vascular disease. The present study reports the case of a 42‑year‑old male who developed PACNS. Magnetic resonance imaging (MRI) scans initially led to a misleading diagnosis of malignant glioma, and surgery was performed. The mass was resected, and a pathological examination confirmed a cerebral vasculitis. Single therapy with high doses of steroid did not improve the patient's condition, while a subsequent lesion appeared on the opposite side one year later. Combined therapy with methylprednisone and cyclophosphamide resulted in a great improvement for the patient. No relapse occurred during one year's follow‑up. Although a tumor‑mimicking PACNS has no established imaging features, a diagnosis of tumor‑mimicking PACNS should be suspected when the MRI reveals inappropriate presentations of a tumor. Greater awareness of this potential manifestation of PACNS may facilitate more prompt diagnosis and treatment.
View References
|
1
|
Salvarani C, Brown RD Jr, Calamia KT,
Christianson TJ, Weigand SD, Miller DV, Giannini C, Meschia JF,
Huston J III and Hunder GG: Primary central nervous system
vasculitis: Analysis of 101 patients. Ann Neurol. 62:442–451. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
MacLaren K, Gillespie J, Shrestha S, Neary
D and Ballardie FW: Primary angiitis of the central nervous system:
Emerging variants. QJM. 98:643–654. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Kraemer M and Berlit P: Primary central
nervous system vasculitis: Clinical experiences with 21 new
European cases. Rheumatol Int. 31:463–472. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Molloy ES, Singhal AB and Calabrese LH:
Tumour-like mass lesion: An under-recognised presentation of
primary angiitis of the central nervous system. Ann Rheum Dis.
67:1732–1735. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Panchal NJ, Niku S and Imbesi SG:
Lymphocytic vasculitis mimicking aggressive multifocal cerebral
neoplasm: MR imaging and MR spectroscopic appearance. AJNR Am
Neuroradiol. 26:642–645. 2005.
|
|
6
|
Kadkhodayan Y, Alreshaid A, Moran CJ,
Cross DT III, Powers WJ and Derdeyn CP: Primary angiitis of the
central nervous system at conventional angiography. Radiology.
233:878–882. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Koopman K, Uyttenboogaart M, Luijckx GJ,
De Keyser J and Vroomen PC: Pitfalls in the diagnosis of reversible
cerebral vasoconstriction syndrome and primary angiitis of the
central nervous system. Eur Neurol. 14:1085–1087. 2007. View Article : Google Scholar
|
|
8
|
Fountain NB and Lopes MB: Control of
primary angiitis of the CNS associated with cerebral amyloid
angiopathy by cyclophosphamide alone. Neurology. 52:660–662. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Carandang CG and Grant AL: Delirium and
isolated angiitis of the central nervous system: A case report and
review. CNS Spectrums. 13:209–213. 2008.PubMed/NCBI
|
|
10
|
Barron TF, Ostrov BE, Zimmerman RA and
Packer RJ: Isolated angiitis of CNS: Treatment with pulse
cyclophosphamide. Pediatr Neurol. 9:73–75. 1993. View Article : Google Scholar : PubMed/NCBI
|
