Open Access

Brain metastases management paradigm shift: A case report and review of the literature

  • Authors:
    • Tamer Refaat
    • Sean Sachdev
    • Brijal Desai
    • Ian Bacchus
    • Saleh Hatoum
    • Plato Lee
    • Orin Bloch
    • James P. Chandler
    • John Kalapurakal
    • Maryanne Hoffman Marymont
  • View Affiliations

  • Published online on: February 8, 2016     https://doi.org/10.3892/mco.2016.772
  • Pages: 487-491
  • Copyright: © Refaat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Brain metastases are the most common intracranial tumors in adults, accounting for over half of all lesions. Whole‑brain radiation therapy (WBRT) has been a cornerstone in the management of brain metastases for decades. Recently, stereotactic radiosurgery (SRS) has been considered as a definitive or postoperative approach instead of WBRT, to minimize the risk of cognitive impairment that may be associated with WBRT. This is the case report of a 74‑year‑old female patient who was diagnosed with lung cancer in November, 2002, and histopathologically confirmed brain metastases in January, 2005. The patient received 5 treatments with Gamma Knife SRS for recurring brain metastases between 2005 and 2014. The patient remains highly functional, with stable intracranial disease at 10 years since first developing brain metastases, and with stable lung disease. Therefore, Gamma Knife SRS is a safe and effective treatment modality for patients with recurrent intracranial metastases, with durable local control and minimal cognitive impairment.
View Figures
View References

Related Articles

Journal Cover

April 2016
Volume 4 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P. ... Marymont, M.H. (2016). Brain metastases management paradigm shift: A case report and review of the literature. Molecular and Clinical Oncology, 4, 487-491. https://doi.org/10.3892/mco.2016.772
MLA
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P., Bloch, O., Chandler, J. P., Kalapurakal, J., Marymont, M. H."Brain metastases management paradigm shift: A case report and review of the literature". Molecular and Clinical Oncology 4.4 (2016): 487-491.
Chicago
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P., Bloch, O., Chandler, J. P., Kalapurakal, J., Marymont, M. H."Brain metastases management paradigm shift: A case report and review of the literature". Molecular and Clinical Oncology 4, no. 4 (2016): 487-491. https://doi.org/10.3892/mco.2016.772