Pemetrexed and bevacizumab‑containing chemotherapy for pleomorphic carcinoma of the lung

  • Authors:
    • Tomohiro Tamura
    • Gen Ohara
    • Katsunori Kagohashi
    • Mio Kawaguchi
    • Koichi Kurishima
    • Hiroaki Satoh
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  • Published online on: January 29, 2016     https://doi.org/10.3892/mco.2016.758
  • Pages: 616-618
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Abstract

Pleomorphic carcinoma of the lung is a rare, highly malignant subtype of lung cancer, with a more aggressive clinical course compared with other types of non‑small‑cell lung cancer (NSCLC). Pemetrexed and bevacizumab are currently evaluated as two of the most reliable chemotherapeutic drugs for advanced NSCLC. We herein report a case of a 68‑ and a 46‑year‑old man with recurrent and chemo‑naïve pleomorphic carcinoma of the lung, respectively, who were treated with a combination of carboplatin, pemetrexed and bevacizumab. The overall survival after the initiation of chemotherapy was 30 and 8 months, respectively. These cases exhibited a relatively long‑term survival with chemotherapy. In the absence of definitive clinical trials, which are unlikely to be performed due to the rarity of this tumor, our cases demonstrated the potential utility of pemetrexed- and bevacizumab‑containing chemotherapy. Our results also suggested that pemetrexed‑containing chemotherapy may be key to the treatment of pleomorphic carcinoma of the lung.
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April 2016
Volume 4 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Tamura, T., Ohara, G., Kagohashi, K., Kawaguchi, M., Kurishima, K., & Satoh, H. (2016). Pemetrexed and bevacizumab‑containing chemotherapy for pleomorphic carcinoma of the lung. Molecular and Clinical Oncology, 4, 616-618. https://doi.org/10.3892/mco.2016.758
MLA
Tamura, T., Ohara, G., Kagohashi, K., Kawaguchi, M., Kurishima, K., Satoh, H."Pemetrexed and bevacizumab‑containing chemotherapy for pleomorphic carcinoma of the lung". Molecular and Clinical Oncology 4.4 (2016): 616-618.
Chicago
Tamura, T., Ohara, G., Kagohashi, K., Kawaguchi, M., Kurishima, K., Satoh, H."Pemetrexed and bevacizumab‑containing chemotherapy for pleomorphic carcinoma of the lung". Molecular and Clinical Oncology 4, no. 4 (2016): 616-618. https://doi.org/10.3892/mco.2016.758