Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)

  • Authors:
    • Giuseppina Della Vittoria Scarpati
    • Francesco Perri
    • Salvatore Pisconti
    • Giuseppe Costa
    • Filippo Ricciardiello
    • Salvatore Del Prete
    • Alberto Napolitano
    • Marco Carraturo
    • Salvatore Mazzone
    • Raffaele Addeo
  • View Affiliations

  • Published online on: January 27, 2016     https://doi.org/10.3892/mco.2016.746
  • Pages: 467-471
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Abstract

Non-melanoma skin cancers (NMSCs) include a heterogeneous group of malignancies arising from the epidermis, comprising squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Merkel cell carcinoma and more rare entities, including malignant pilomatrixoma and sebaceous gland tumours. The treatment of early disease depends primarily on surgery. In addition, certain patients present with extensive local invasion or metastasis, which renders these tumours surgically unresectable. Improving the outcome of radiotherapy through the use of concurrent systemic therapy has been demonstrated in several locally advanced cancer‑treatment paradigms. Recently, agents targeting the human epidermal growth factor receptor (EGFR) have exhibited a consolidated activity in phase II clinical trials and case series reports. Cetuximab is a monoclonal antibody that binds to and completely inhibits the EGFR, which has been revealed to be up‑regulated in a variety of SCCs, including NMSCs. The present review aimed to summarize the role of anti‑EGFR agents in the predominant types of NMSC, including SCC and BCC, and focuses on the cetuximab‑based studies, highlighting the biological rationale of this therapeutic option. In addition, the importance of the association between cetuximab and radiotherapy for locally advanced NMSC is discussed.
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April 2016
Volume 4 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S. ... Addeo, R. (2016). Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review). Molecular and Clinical Oncology, 4, 467-471. https://doi.org/10.3892/mco.2016.746
MLA
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S., Napolitano, A., Carraturo, M., Mazzone, S., Addeo, R."Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)". Molecular and Clinical Oncology 4.4 (2016): 467-471.
Chicago
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S., Napolitano, A., Carraturo, M., Mazzone, S., Addeo, R."Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)". Molecular and Clinical Oncology 4, no. 4 (2016): 467-471. https://doi.org/10.3892/mco.2016.746