Post‑transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report

  • Authors:
    • Man Fai Law
    • Hay Nun Chan
    • Ho Kei Lai
    • Chung Yin Ha
    • Celia Ng
    • Yiu Ming Yeung
    • Sze Fai Yip
  • View Affiliations

  • Published online on: September 19, 2016     https://doi.org/10.3892/mco.2016.1024
  • Pages: 610-612
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Abstract

Post-transplant lymphoproliferative disorder (PTLD) is associated with a variety of clinical presentations, but rarely involves the skin. We herein report a case of PTLD presenting with skin ulceration in a renal transplant recipient. A biopsy of the ulcer confirmed the diagnosis of diffuse large B‑cell lymphoma. The patient was initially treated with immunosuppression reduction, but the skin ulcer persisted. He was then treated with two courses of chemotherapy, but his condition was complicated with cryptococcal infection. Antifungal agents were administered to control the fungal infection. The patient later developed lymphoma recurrence and was successfully treated with single‑agent rituximab. The patient remains well 6 years after treatment, with no evidence of disease relapse. Therefore, PTLD may manifest as skin lesions and physicians must be aware of this rare presentation.
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November 2016
Volume 5 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Law, M.F., Chan, H.N., Lai, H.K., Ha, C.Y., Ng, C., Yeung, Y.M., & Yip, S.F. (2016). Post‑transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report. Molecular and Clinical Oncology, 5, 610-612. https://doi.org/10.3892/mco.2016.1024
MLA
Law, M. F., Chan, H. N., Lai, H. K., Ha, C. Y., Ng, C., Yeung, Y. M., Yip, S. F."Post‑transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report". Molecular and Clinical Oncology 5.5 (2016): 610-612.
Chicago
Law, M. F., Chan, H. N., Lai, H. K., Ha, C. Y., Ng, C., Yeung, Y. M., Yip, S. F."Post‑transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report". Molecular and Clinical Oncology 5, no. 5 (2016): 610-612. https://doi.org/10.3892/mco.2016.1024