High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study

  • Authors:
    • Mei Li
    • Shumei Yan
    • Muyan Cai
    • Jiabin Lu
    • Meifang Zhang
    • Ping Yang
    • Rongzhen Luo
  • View Affiliations

  • Published online on: December 11, 2015     https://doi.org/10.3892/mco.2015.707
  • Pages: 159-165
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Abstract

Human enhancer of filamentation 1 (HEF1), a scaffold protein, is highly expressed in a variety of cancer types and is involved cancer cell growth, migration and invasion. The prognostic value of HEF1 in hepatocellular carcinoma (HCC) remains to be elucidated. The aim of the present study was to assess the association between the expression of HEF1, the clinical/pathological parameters and survival in HCC. In the present study, immunohistochemistry was performed to investigate the protein expression of HEF1 in 123 hepatocellular carcinoma tissues and their adjacent normal liver tissues. Spearman's rank correlation, Kaplan‑Meier plots and Cox regression model were used to analyze the data. Overexpression of HEF1 protein was observed in HCC tissue when compared with their adjacent non‑malignant liver tissue. High expression of HEF1 correlated with higher advanced tumor, node, metastasis (TNM) stage and vascular invasion (P<0.05). In univariate and multivariate analysis, the expression of HEF1 was identified as an independent prognostic factor in the 123 patients with HCC. In subgroup analysis, high expression of HEF1 correlated with a poorer prognosis in advanced (TNM III+IV) stages (P<0.05). These findings demonstrated the potential value of detecting the expression of HEF1 by immunohistochemistry as a prognostic biomarker and therapeutic target for patients with HCC.
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February 2016
Volume 4 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Li, M., Yan, S., Cai, M., Lu, J., Zhang, M., Yang, P., & Luo, R. (2016). High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study. Molecular and Clinical Oncology, 4, 159-165. https://doi.org/10.3892/mco.2015.707
MLA
Li, M., Yan, S., Cai, M., Lu, J., Zhang, M., Yang, P., Luo, R."High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study". Molecular and Clinical Oncology 4.2 (2016): 159-165.
Chicago
Li, M., Yan, S., Cai, M., Lu, J., Zhang, M., Yang, P., Luo, R."High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study". Molecular and Clinical Oncology 4, no. 2 (2016): 159-165. https://doi.org/10.3892/mco.2015.707