Cyclophosphamide combined with mitoxantrone and cytarabine is an effective salvage regimen for patients with acute myeloid leukemia who experienced primary induction failure or relapse

  • Authors:
    • Shuning Wei
    • Yingchang Mi
    • Hui Wei
    • Dong Lin
    • Kanqi Liu
    • Benfa Gong
    • Guangji Zhang
    • Yuntao Liu
    • Yan Li
    • Chunlin Zhou
    • Bingcheng Liu
    • Wei Li
    • Jianxiang Wang
  • View Affiliations

  • Published online on: November 16, 2015     https://doi.org/10.3892/mco.2015.679
  • Pages: 285-289
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Abstract

Salvage regimens containing mitoxantrone have been successfully used for the treatment of primary induction failure or relapsed acute myeloid leukemia. However, the combination of cyclophosphamide with mitoxantrone and cytarabine (MAC) has never been assessed in these patients. A total of 91 patients, including patients with primary induction failure (n=44) and relapsed (n=47), were treated with a salvage MAC regimen, which consisted of mitoxantrone, cytarabine and cyclophosphamide. The overall complete remission rate was 74.7 (68/91) and 72.7% (32/44) for primary induction failure, and 76.6% (36/47) for relapsed patients. The overall survival rate and disease‑free survival rate were 72.1 and 59.7% at 1 year, 42.9 and 47.1% at 3 years, and 36.7 and 43.0% at 5 years, respectively. Only one patient succumbed to mortality during induction therapy. The toxicity level was acceptable. Therefore, the present study demonstrated that MAC is a highly effective and well‑tolerated regimen for salvage in patients experiencing primary induction failure or relapse. This treatment significantly improved the prognosis.
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February 2016
Volume 4 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Wei, S., Mi, Y., Wei, H., Lin, D., Liu, K., Gong, B. ... Wang, J. (2016). Cyclophosphamide combined with mitoxantrone and cytarabine is an effective salvage regimen for patients with acute myeloid leukemia who experienced primary induction failure or relapse. Molecular and Clinical Oncology, 4, 285-289. https://doi.org/10.3892/mco.2015.679
MLA
Wei, S., Mi, Y., Wei, H., Lin, D., Liu, K., Gong, B., Zhang, G., Liu, Y., Li, Y., Zhou, C., Liu, B., Li, W., Wang, J."Cyclophosphamide combined with mitoxantrone and cytarabine is an effective salvage regimen for patients with acute myeloid leukemia who experienced primary induction failure or relapse". Molecular and Clinical Oncology 4.2 (2016): 285-289.
Chicago
Wei, S., Mi, Y., Wei, H., Lin, D., Liu, K., Gong, B., Zhang, G., Liu, Y., Li, Y., Zhou, C., Liu, B., Li, W., Wang, J."Cyclophosphamide combined with mitoxantrone and cytarabine is an effective salvage regimen for patients with acute myeloid leukemia who experienced primary induction failure or relapse". Molecular and Clinical Oncology 4, no. 2 (2016): 285-289. https://doi.org/10.3892/mco.2015.679