Specific organ metastases and survival in metastatic non‑small‑cell lung cancer

  • Authors:
    • Tomohiro Tamura
    • Koichi Kurishima
    • Kensuke Nakazawa
    • Katsunori Kagohashi
    • Hiroichi Ishikawa
    • Hiroaki Satoh
    • Nobuyuki Hizawa
  • View Affiliations

  • Published online on: September 4, 2014     https://doi.org/10.3892/mco.2014.410
  • Pages: 217-221
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Abstract

the present retrospective study was performed to evaluate the clinicopathological characteristics associated with distant metastasis from non‑small‑cell lung cancer (NSCLC). The records of NSCLC patients with metastasis at the time of diagnosis between 1999 and 2012 were reviewed. Of the consecutive 1,542 NSCLC patients diagnosed during the study period, 729 (47.3%) patients presented with distant metastasis. Among those 729 metastatic NSCLC patients, 250 (34.3%), 234 (32.1%), 207 (28.4%), 122 (16.7%), 98 (13.4%) and 69 (9.5%) had bone, lung, brain, adrenal gland, liver and extrathoracic lymph node metastasis, respectively. In a multivariate analysis using the Cox proportional hazards model, liver and adrenal gland metastases were unfavorable prognostic factors. However, brain and bone metastases were not statistically significant prognostic factors. Using a logistic regression analysis, metastasis to the adrenal glands and the presence of pleural and̸or pericardial fluid effusion were correlated with a poor performance status. Therefore, when planning the treatment of NSCLC patients, particularly those with liver and adrenal gland metastases, we should take into consideration information regarding these unfavorable organ metastases.
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January 2015
Volume 3 Issue 1

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APA
Tamura, T., Kurishima, K., Nakazawa, K., Kagohashi, K., Ishikawa, H., Satoh, H., & Hizawa, N. (2015). Specific organ metastases and survival in metastatic non‑small‑cell lung cancer. Molecular and Clinical Oncology, 3, 217-221. https://doi.org/10.3892/mco.2014.410
MLA
Tamura, T., Kurishima, K., Nakazawa, K., Kagohashi, K., Ishikawa, H., Satoh, H., Hizawa, N."Specific organ metastases and survival in metastatic non‑small‑cell lung cancer". Molecular and Clinical Oncology 3.1 (2015): 217-221.
Chicago
Tamura, T., Kurishima, K., Nakazawa, K., Kagohashi, K., Ishikawa, H., Satoh, H., Hizawa, N."Specific organ metastases and survival in metastatic non‑small‑cell lung cancer". Molecular and Clinical Oncology 3, no. 1 (2015): 217-221. https://doi.org/10.3892/mco.2014.410