Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer

  • Authors:
    • Takeshi Kajiwara
    • Yoichi Hiasa
    • Tomohiro Nishina
    • Toshihiko Matsumoto
    • Shinichiro Hori
    • Seijin Nadano
    • Haruo Iguchi
    • Satoru Takeji
    • Eiji Tsubouchi
    • Yoshio Ikeda
    • Morikazu Onji
  • View Affiliations

  • Published online on: January 7, 2014     https://doi.org/10.3892/mco.2014.238
  • Pages: 313-321
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Abstract

Positron emission tomography/computed tomography (PET/CT) with 18F‑fluoro‑2‑deoxyglucose (FDG‑PET/CT) has become established in cancer imaging, and derived maximum standardized uptake values (SUVmax) add functional information regarding cancer, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to determine the clinical significance and association of tumor progression using SUVmax derived from PET/CT images in patients with ESCC. In total, 101 patients with ESCC were assessed using FDG‑PET/CT and the SUVmax was then compared with the clinical backgrounds and prognoses of the patients. Endoscopic ESCC biopsy specimens were obtained in order to analyze mRNA expression relative to tumor progression. The results showed that values for SUVmax were significantly higher in patients with tumor progression factors, particularly those with lymph node metastasis. Analysis of receiver operating characteristics curves revealed an optimum SUVmax cut‑off value of 10.26 for node‑positive disease. Patients with SUVmax ≥10.26 had gene alterations with epithelial‑mesenchymal transition (EMT) and significantly worse overall survival (P=0.0012). A higher SUVmax in patients with ESCC was associated with lymph node metastasis and a poorer prognosis. Thus, the SUVmax may reflect the potential of EMT in patients with ESCC.
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March 2014
Volume 2 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S. ... Onji, M. (2014). Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer. Molecular and Clinical Oncology, 2, 313-321. https://doi.org/10.3892/mco.2014.238
MLA
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S., Iguchi, H., Takeji, S., Tsubouchi, E., Ikeda, Y., Onji, M."Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer". Molecular and Clinical Oncology 2.2 (2014): 313-321.
Chicago
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S., Iguchi, H., Takeji, S., Tsubouchi, E., Ikeda, Y., Onji, M."Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 313-321. https://doi.org/10.3892/mco.2014.238