Brain metastasis as an isolated late recurrence in small‑cell lung cancer

  • Authors:
    • Koichi Kurishima
    • Shinsuke Homma
    • Katsunori Kagohashi
    • Kunihiko Miyazaki
    • Mio Kawaguchi
    • Hiroaki Satoh
    • Nobuyuki Hizawa
  • View Affiliations

  • Published online on: December 31, 2013     https://doi.org/10.3892/mco.2013.236
  • Pages: 305-307
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Abstract

The brain is one of the most common sites of metastasis of small‑cell lung cancer (SCLC). In this study, we reported 6 cases with isolated brain relapse of SCLC ≥1 year after the completion of the initial treatment for SCLC. Of the 6 patients, 2 had a solitary brain metastasis and 4 had ≥2 brain metastatic sites. The metastases were identified during a regular check-up computed tomography (CT) scan and were successfully treated. The median interval from the initial diagnosis to the development of brain metastasis was 16 months (range, 13-30 months). All patients received whole‑brain irradiation and achieved a complete response. Only one patient developed disturbances of the higher cerebral function. The median interval from whole‑brain irradiation to death or last follow-up was 33 months (range, 8-90 months). To the best of our knowledge, these are the first reported cases with isolated brain relapse of SCLC. Although a rare finding, clinicians should be alert on the possibility of such recurrence, particularly in patients who refused prophylactic cranial irradiation.
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March 2014
Volume 2 Issue 2

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APA
Kurishima, K., Homma, S., Kagohashi, K., Miyazaki, K., Kawaguchi, M., Satoh, H., & Hizawa, N. (2014). Brain metastasis as an isolated late recurrence in small‑cell lung cancer. Molecular and Clinical Oncology, 2, 305-307. https://doi.org/10.3892/mco.2013.236
MLA
Kurishima, K., Homma, S., Kagohashi, K., Miyazaki, K., Kawaguchi, M., Satoh, H., Hizawa, N."Brain metastasis as an isolated late recurrence in small‑cell lung cancer". Molecular and Clinical Oncology 2.2 (2014): 305-307.
Chicago
Kurishima, K., Homma, S., Kagohashi, K., Miyazaki, K., Kawaguchi, M., Satoh, H., Hizawa, N."Brain metastasis as an isolated late recurrence in small‑cell lung cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 305-307. https://doi.org/10.3892/mco.2013.236