Prognostic significance of NPM1 mutations in acute myeloid leukemia: A meta-analysis

  • Authors:
    • Yanfeng Liu
    • Pengcheng He
    • Feng Liu
    • Lili Shi
    • Huachao Zhu
    • Jing Zhao
    • Yuan Wang
    • Xiaoyan Chen
    • Mei Zhang
  • View Affiliations

  • Published online on: December 10, 2013     https://doi.org/10.3892/mco.2013.222
  • Pages: 275-281
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Abstract

Nucleophosmin 1 (NPM1) mutations have been identified in a substantial number of patients with acute myeloid leukemia (AML). Favorable outcomes in AML cases with NPM1 mutations have been previously reported. However, widely differing survival estimates have been indicated. Therefore, a meta‑analysis of nine studies including a total of 4509 subjects was performed. The frequency of NPM1 mutations was found to be 6.45-56.08%. NPM1‑mutation type (NPM1‑mt) patients had >2-fold higher odds of achieving complete remission compared with NPM1-wild-type (NPM1‑wt). The summary hazard ratio (HR) of NPM1-mt/NPM1-wt for disease-free survival (DFS) and OS was 0.67 and 0.63, respectively. In conclusion, these findings suggest that the NPM1 mutation has a favorable effect on the outcome for AML. The present meta‑analysis was based on data abstracted from observational studies. However, the results obtained may justify the risk-adapted therapeutic strategies for AML according to the NPM1 status.
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March 2014
Volume 2 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Zhao, J. ... Zhang, M. (2014). Prognostic significance of NPM1 mutations in acute myeloid leukemia: A meta-analysis. Molecular and Clinical Oncology, 2, 275-281. https://doi.org/10.3892/mco.2013.222
MLA
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Zhao, J., Wang, Y., Chen, X., Zhang, M."Prognostic significance of NPM1 mutations in acute myeloid leukemia: A meta-analysis". Molecular and Clinical Oncology 2.2 (2014): 275-281.
Chicago
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Zhao, J., Wang, Y., Chen, X., Zhang, M."Prognostic significance of NPM1 mutations in acute myeloid leukemia: A meta-analysis". Molecular and Clinical Oncology 2, no. 2 (2014): 275-281. https://doi.org/10.3892/mco.2013.222