A new strategy of promoting cisplatin chemotherapeutic efficiency by targeting endoplasmic reticulum stress (Review)

  • Authors:
    • Ye Xu
    • Chunyan Wang
    • Zhixin Li
  • View Affiliations

  • Published online on: October 18, 2013     https://doi.org/10.3892/mco.2013.202
  • Pages: 3-7
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Abstract

Cisplatin (cis‑diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents and is widely used in the treatment of solid tumors. However, its side effects and acquired resistance gained during the course of treatment may limit its usage. It is generally considered to be a cytotoxic drug that kills cancer cells by damaging their DNA and inhibiting DNA synthesis to induce apoptosis via the mitochondrial death pathway or through plasma membrane disruption, triggering the Fas death receptor pathway. The endoplasmic reticulum (ER) is one of the most important protein‑folding compartments within the cell and an intracellular Ca2+ storage organelle. The ER contains a number of molecular chaperones, which may play an important role in determining cellular sensitivity to ER stress and apoptosis. The aim of this review was to summarize our current understanding regarding the mechanisms of ER stress response by which cisplatin induces cell death and the basis for cisplatin resistance. various aspects were addressed, including the two‑way regulation of ER stress, the involvement of ER stress in cisplatin‑induced cell death and drug resistance and the drugs enhancing cisplatin‑induced cell death by interfering with ER stress. An understanding of how ER stress signaling pathways regulate cisplatin‑induced cell death may enable the development of more effective therapeutic strategies for the treatment of cancer.
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January 2014
Volume 2 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Xu, Y., Wang, C., & Li, Z. (2014). A new strategy of promoting cisplatin chemotherapeutic efficiency by targeting endoplasmic reticulum stress (Review). Molecular and Clinical Oncology, 2, 3-7. https://doi.org/10.3892/mco.2013.202
MLA
Xu, Y., Wang, C., Li, Z."A new strategy of promoting cisplatin chemotherapeutic efficiency by targeting endoplasmic reticulum stress (Review)". Molecular and Clinical Oncology 2.1 (2014): 3-7.
Chicago
Xu, Y., Wang, C., Li, Z."A new strategy of promoting cisplatin chemotherapeutic efficiency by targeting endoplasmic reticulum stress (Review)". Molecular and Clinical Oncology 2, no. 1 (2014): 3-7. https://doi.org/10.3892/mco.2013.202