Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients

  • Authors:
    • Yi Han
    • Guo Li
    • Chongyu Su
    • Hua Ren
    • Xiangyang Chu
    • Qiuyue Zhao
    • Yanjun Zhu
    • Zitong Wang
    • Bin Hu
    • Guangyu An
    • Jingbo Kang
    • Wei Wang
    • Daping Yu
    • Xiaoyun Song
    • Ning Xiao
    • Yunsong Li
    • Xia Li
    • Huiyi Yang
    • Gang Yu
    • Zhidong Liu
  • View Affiliations

  • Published online on: July 23, 2013     https://doi.org/10.3892/mco.2013.153
  • Pages: 887-893
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Abstract

Personalized medicine has become essential in the treatment of lung cancer. However, the lung cancer-related gene expression profiles in non-small cell lung cancer (NSCLC) patients have not been elucidated. In this study, the correlation between gene expression profiles and clinicopathological characteristics was investigated in NSCLC patients. A total of 95 patients were enrolled in this study. The mRNA expression levels of 14 genes were assessed by multiplex branched DNA liquidchip (MBL) technology and data on 9 clinicopathological characteristics of patients were collected simultaneously. The correlation between gene expression and clinicopathological characteristics was investigated. Out of the 9 clinicopathological parameters, 6 were associated with several of the 14 genes analyzed. Patient gender was associated with TYMS and TOP2A. Clinical stage was associated with VEGFR2, KIT and HER2. there was weak correlation between primary tumor size of ≤3 cm and the expression level of KIT. The mRNA expression levels of VEGFR2 and HER2 correlated with distant metastasis. BRCA1, TYMS, TOP2A and HER2 were associated with histological type. Smoking correlated with higher expression levels of BRCA1, TYMS and TOP2A and lower expression levels of PDGFRβ. The results were suggestive of correlation between the clinicopathological parameters of the NSCLC patients and the mRNA expression levels of certain lung cancer-related genes, including BRCA1, TYMS, TOP2A, PDGFRβ, VEGFR2, KIT and HER2.
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September 2013
Volume 1 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Han, Y., Li, G., Su, C., Ren, H., Chu, X., Zhao, Q. ... Liu, Z. (2013). Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients. Molecular and Clinical Oncology, 1, 887-893. https://doi.org/10.3892/mco.2013.153
MLA
Han, Y., Li, G., Su, C., Ren, H., Chu, X., Zhao, Q., Zhu, Y., Wang, Z., Hu, B., An, G., Kang, J., Wang, W., Yu, D., Song, X., Xiao, N., Li, Y., Li, X., Yang, H., Yu, G., Liu, Z."Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients". Molecular and Clinical Oncology 1.5 (2013): 887-893.
Chicago
Han, Y., Li, G., Su, C., Ren, H., Chu, X., Zhao, Q., Zhu, Y., Wang, Z., Hu, B., An, G., Kang, J., Wang, W., Yu, D., Song, X., Xiao, N., Li, Y., Li, X., Yang, H., Yu, G., Liu, Z."Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients". Molecular and Clinical Oncology 1, no. 5 (2013): 887-893. https://doi.org/10.3892/mco.2013.153