Clinical characteristics and prognostic significance of 92 cases of patients with primary mixed‑histology lung cancer

  • Authors:
    • Pengbo Deng
    • Chengping Hu
    • Lihua Zhou
    • Yuanyuan Li
    • Li Huang
  • View Affiliations

  • Published online on: June 14, 2013     https://doi.org/10.3892/mco.2013.137
  • Pages: 863-868
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mixed‑histology primary lung cancer is a rare type of lung cancer, where data regarding epidemiology, clinical features and prognosis of survival are limited. The aim of this study was to analyze the clinical characteristics of patients with mixed-histology lung tumors, and to investigate the association between clinical characteristics, treatment and prognosis. Between January, 1999 and September, 2008, 1,842 patients were diagnosed with primary lung tumors. Of these, 92 presented a mixed histological pattern. Patient clinical characteristics, clinical tumor‑node‑metastasis (TNM) staging, diagnostic methods, treatment and survival data were collected in order to be retrospectively analyzed. Differences between the frequencies were examined using the χ2 test and survival rates using the Kaplan-Meier method. The log‑rank test was used to compare the survival curves and a probability value <5% (P<0.05) was considered to indicate a statistically significant difference. Of the 92 lung cancer patients (4.99%) with a mixed histological pattern, most were adenosquamous carcinomas. Patients included 75 men and 17 women with a mean age of 56 years. Most cases were in late stage and 64 patients had metastasis. The 1‑, 2‑ and 3‑year survival of 52 mixed‑histology and 54 non‑small cell lung cancer (NSCLC) patients with resection who were successfully followed up, was 63.5, 23.1, 9.6 and 81.5, 48.1, 27.7% (P=0.013). The median survival time of mixed‑histology lung cancer patients treated with surgery plus adjuvant therapy and surgery alone was 22 and 12 months, respectively (P=0.002). Mixed‑histology lung cancer is characterized by higher malignancy and poor prognosis. However, surgery plus adjuvant therapy is able to prolong survival, compared to surgery alone.
View Figures
View References

Related Articles

Journal Cover

September 2013
Volume 1 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Deng, P., Hu, C., Zhou, L., Li, Y., & Huang, L. (2013). Clinical characteristics and prognostic significance of 92 cases of patients with primary mixed‑histology lung cancer. Molecular and Clinical Oncology, 1, 863-868. https://doi.org/10.3892/mco.2013.137
MLA
Deng, P., Hu, C., Zhou, L., Li, Y., Huang, L."Clinical characteristics and prognostic significance of 92 cases of patients with primary mixed‑histology lung cancer". Molecular and Clinical Oncology 1.5 (2013): 863-868.
Chicago
Deng, P., Hu, C., Zhou, L., Li, Y., Huang, L."Clinical characteristics and prognostic significance of 92 cases of patients with primary mixed‑histology lung cancer". Molecular and Clinical Oncology 1, no. 5 (2013): 863-868. https://doi.org/10.3892/mco.2013.137