Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease

  • Authors:
    • Mitsuaki Ishida
    • Hidetoshi Okabe
  • View Affiliations

  • Published online on: April 18, 2013     https://doi.org/10.3892/mco.2013.106
  • Pages: 621-624
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Abstract

Aldehyde dehydrogenase (ALDH) is an enzyme responsible for oxidizing aldehydes to carbonic acids. ALDH1 is an isoform that is thought to be a stem cell marker as it is highly expressed in the stem cells of various organs. However, its expression in basal cell carcinoma (BCC), actinic keratosis (AK) and Bowen's disease (BD) of the skin has not yet been analyzed. Twenty‑five consecutive operative cases each of BCC, AK and BD, as well as 10 normal skin tissues were assessed for ALDH1 expression by immunohistochemistry. In normal skin, ALDH1 expression was observed in the suprabasal cells of the follicular infundibulum, inner cells of the outer root sheath and sebocytes. BCC cases (88%) showed no or focal-positive immunoreactivity for ALDH1. Focal immunopositivity for ALDH1 was observed in 44% of AK cases, while the remaining cases were ALDH1‑negative. By contrast, diffuse positive immunoreactivity for ALDH1 was observed in 64% of BD cases. Differential expression patterns of ALDH1 in AK and BD may reflect the distinct cells of origin of these two conditions. Moreover, a low ALDH1 expression in BCC may also reflect the possible origin of BCC, the basal cells of the outer root sheath.
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July 2013
Volume 1 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Ishida, M., & Ishida, M. (2013). Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease . Molecular and Clinical Oncology, 1, 621-624. https://doi.org/10.3892/mco.2013.106
MLA
Ishida, M., Okabe, H."Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease ". Molecular and Clinical Oncology 1.4 (2013): 621-624.
Chicago
Ishida, M., Okabe, H."Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease ". Molecular and Clinical Oncology 1, no. 4 (2013): 621-624. https://doi.org/10.3892/mco.2013.106