Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention (Review)

  • Authors:
    • Ying Wang
    • Wenli Ma
    • Wenling Zheng
  • View Affiliations

  • Published online on: October 18, 2012     https://doi.org/10.3892/mco.2012.36
  • Pages: 215-219
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Abstract

Deguelin is a natural compound of the flavonoid family products isolated from Derris trifoliata Lour. or Mundulea sericea (Leguminosae). It exhibited significant anti-tumorigenesis and anti-proliferative activity in various types of cancer both in vitro and in vivo. Deguelin induced cell apoptosis by blocking anti-apoptotic pathways, such as PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin, while inhibiting tumor cell propagation and malignant transformation through p27-cyclinE-pRb-E2F1 cell cycle control and HIF-1α-VEGF anti-angiogenic pathways. In pre-clinical trials, deguelin markedly decreased the tumor incidence. These biological findings identified deguelin as a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention and chemotherapy.
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March 2013
Volume 1 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Wang, Y., Ma, W., & Zheng, W. (2013). Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention (Review). Molecular and Clinical Oncology, 1, 215-219. https://doi.org/10.3892/mco.2012.36
MLA
Wang, Y., Ma, W., Zheng, W."Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention (Review)". Molecular and Clinical Oncology 1.2 (2013): 215-219.
Chicago
Wang, Y., Ma, W., Zheng, W."Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention (Review)". Molecular and Clinical Oncology 1, no. 2 (2013): 215-219. https://doi.org/10.3892/mco.2012.36