Epigenetic control of epithelial-mesenchymal-transition in human cancer (Review)

  • Authors:
    • Tobias Kiesslich
    • Martin Pichler
    • Daniel Neureiter
  • View Affiliations

  • Published online on: September 25, 2012     https://doi.org/10.3892/mco.2012.28
  • Pages: 3-11
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Development and tissue homeostasis as well as carcinogenesis share the evolutionary conserved process of epithelial-mesenchymal transition (EMT). EMT enables differentiated epithelial cells to trans-differentiate to a mesenchymal phenotype which is associated with diverse cellular properties including altered morphology, migration and invasion and stemness. In physiological development and tissue homeostasis, EMT exerts beneficial functions for structured tissue formation and maintenance. Under pathological conditions, EMT causes uncontrolled tissue repair and organ fibrosis, as well as the induction of tumor growth, angiogenesis and metastasis in the context of cancer progression. Particularly, the metastatic process is essentially linked to diverse EMT-driven functions which give the mesenchymal differentiated tumor cells the capacity to migrate and form micrometastases in distant organs. Recent analyses of the mechanisms controlling EMT revealed a significant epigenetic regulatory impact reflecting the reversible nature of EMTs. As several approaches of epigenetic therapy are already under clinical evaluation, including inhibitors of DNA methyl transferase and histone deacetylase, targeting the epigenetic regulation of EMT may represent a promising therapeutic option in the future. Therefore, we undertook this review to reassess the current knowledge on the roles of epigenetic control in the regulation of EMT in human cancer. These recent findings are discussed in view of their implications on future diagnostic and therapeutic strategies.
View Figures
View References

Related Articles

Journal Cover

January 2013
Volume 1 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Kiesslich, T., Pichler, M., & Neureiter, D. (2013). Epigenetic control of epithelial-mesenchymal-transition in human cancer (Review). Molecular and Clinical Oncology, 1, 3-11. https://doi.org/10.3892/mco.2012.28
MLA
Kiesslich, T., Pichler, M., Neureiter, D."Epigenetic control of epithelial-mesenchymal-transition in human cancer (Review)". Molecular and Clinical Oncology 1.1 (2013): 3-11.
Chicago
Kiesslich, T., Pichler, M., Neureiter, D."Epigenetic control of epithelial-mesenchymal-transition in human cancer (Review)". Molecular and Clinical Oncology 1, no. 1 (2013): 3-11. https://doi.org/10.3892/mco.2012.28