The proliferation marker thymidine kinase 1 in clinical use (Review)

  • Authors:
    • Ji Zhou
    • Ellen He
    • Sven Skog
  • View Affiliations

  • Published online on: September 4, 2012     https://doi.org/10.3892/mco.2012.19
  • Pages: 18-28
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Abstract

Tumor-related biomarkers are used for the diagnosis, prognosis and monitoring of treatments and follow-up of cancer patients, although only a few are fully accepted for the detection of invisible/visible tumors in health screening. Thymidine kinase 1 (TK1), a cell cycle‑dependent and thus a proliferation‑related marker, has been extensively studied during the last decades, using both biochemical and immunological techniques. Therefore, TK1 is an emerging potential proliferating biomarker in oncology that may be used for the prognosis and monitoring of tumor therapy, relapse and survival. In addition, TK1 concentration in serum (STK1p) is a useful biomarker in healthy screening for the detection of potential malignancy development as well as the identification of early‑stage tumors, with a few false-positive cases (ROC value, 0.96; tumor proliferation sensitivity, 0.80; specificity, 0.99). In this review, we examine results regarding the expression of STK1p and TK1 in relation to cancer patients and STK1p in health screening published between 2000 and 2012. The use of tumor-related markers recommended by international cancer organizations is also discussed. This review provides valuable information for applications in tumor patients, in health screening and for cancer research.
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January 2013
Volume 1 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Zhou, J., He, E., & Skog, S. (2013). The proliferation marker thymidine kinase 1 in clinical use (Review). Molecular and Clinical Oncology, 1, 18-28. https://doi.org/10.3892/mco.2012.19
MLA
Zhou, J., He, E., Skog, S."The proliferation marker thymidine kinase 1 in clinical use (Review)". Molecular and Clinical Oncology 1.1 (2013): 18-28.
Chicago
Zhou, J., He, E., Skog, S."The proliferation marker thymidine kinase 1 in clinical use (Review)". Molecular and Clinical Oncology 1, no. 1 (2013): 18-28. https://doi.org/10.3892/mco.2012.19