TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt

  • Authors:
    • Bo K. Sun
    • Joo-Hang Kim
    • Hoan N. Nguyen
    • So Y. Kim
    • Seeun Oh
    • Yong J. Lee
    • Jae J. Song
  • View Affiliations

  • Published online on: January 1, 2011     https://doi.org/10.3892/ijo_00000845
  • Pages: 249-256
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Abstract

We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is simultaneously involved in the rapid degradation of TRAIL receptors and Akt phosphorylation during TRAIL treatment. Here, we show that Akt phosphorylation is not exclusively responsible for acquired TRAIL resistance. Akt catalytic activation is known to increase during metabolic oxidative stress, but we show that TRAIL also dramatically induces the catalytic activation of Akt in TRAIL-sensitive cells, but not in TRAIL-resistant cells. This suggests that Akt catalytic activation during TRAIL-induced apoptosis is likely to play a compensatory role in the maintenance of cell homeostasis. In addition, activated p38 and phosphorylated HSP27 were found to act as downstream effector molecules of p38 during TRAIL treatment and were shown to be responsible for increased Akt catalytic and invasive activities.

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January 2011
Volume 38 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sun, B.K., Kim, J., Nguyen, H.N., Kim, S.Y., Oh, S., Lee, Y.J., & Song, J.J. (2011). TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt. International Journal of Oncology, 38, 249-256. https://doi.org/10.3892/ijo_00000845
MLA
Sun, B. K., Kim, J., Nguyen, H. N., Kim, S. Y., Oh, S., Lee, Y. J., Song, J. J."TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt". International Journal of Oncology 38.1 (2011): 249-256.
Chicago
Sun, B. K., Kim, J., Nguyen, H. N., Kim, S. Y., Oh, S., Lee, Y. J., Song, J. J."TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt". International Journal of Oncology 38, no. 1 (2011): 249-256. https://doi.org/10.3892/ijo_00000845