Open Access

SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis

  • Authors:
    • Susanne Schüler
    • Sandra Diersch
    • Rainer Hamacher
    • Roland M. Schmid
    • Dieter Saur
    • Günter Schneider
  • View Affiliations

  • Published online on: January 1, 2011     https://doi.org/10.3892/ijo_00000841
  • Pages: 219-225
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis and no effective conservative therapy exists. Although the F-box protein S-phase kinase associated protein 2 (SKP2) is highly expressed and regulates cell cycle progression in PDAC, alternative SKP2 functions in PDAC are unknown. Using RNA interference we now demonstrate that SKP2 confers resistance of a subset of PDAC cell lines towards the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not the topoisomerase II inhibitor etoposide. We observed accelerated cleavage of the BH3-only protein Bid and augmented downregulation of cFLIPL, XIAP and MCL1 upon treatment of SKP2-depleted MiaPaCa2 cells with TRAIL. Our data disclose a novel SKP2 function in PDAC cells and therefore define SKP2 as a molecular target.

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January 2011
Volume 38 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Schüler, S., Diersch, S., Hamacher, R., Schmid, R.M., Saur, D., & Schneider, G. (2011). SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis. International Journal of Oncology, 38, 219-225. https://doi.org/10.3892/ijo_00000841
MLA
Schüler, S., Diersch, S., Hamacher, R., Schmid, R. M., Saur, D., Schneider, G."SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis". International Journal of Oncology 38.1 (2011): 219-225.
Chicago
Schüler, S., Diersch, S., Hamacher, R., Schmid, R. M., Saur, D., Schneider, G."SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis". International Journal of Oncology 38, no. 1 (2011): 219-225. https://doi.org/10.3892/ijo_00000841