CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas

  • Authors:
    • Soon A. Park
    • Chung Heon Ryu
    • Seong Muk Kim
    • Jung Yeon Lim
    • Sang In Park
    • Chang Hyun Jeong
    • Jin Ae Jun
    • Ji Hyeon Oh
    • Sun Hwa Park
    • Wonil Oh
    • Sin-Soo Jeun
  • View Affiliations

  • Published online on: January 1, 2011     https://doi.org/10.3892/ijo_00000828
  • Pages: 97-103
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Abstract

Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, stromal cell-derived factor-1α (SDF-1α) has been identified as a key molecule related to the tropism of MSC in many cancers containing gliomas. In this study, we found that overexpression of the SDF-1α receptor, CXCR4, on human umbilical cord blood-derived MSCs (hUCB-MSCs) enhanced the migratory capacity of MSCs toward gliomas. We showed that hUCB-MSCs have the migration ability toward the glioma cell lines and primary glioma cells. SDF-1α treatment increased the migration capacity of hUCB-MSCs in a dose-dependent manner and inhibition of SDF-1α or CXCR4 by treatment with the anti-SDF-1α or the CXCR4 antagonist AMD3100 blocked the migration capacity of hUCB-MSCs toward glioma cells. Furthermore, CXCR4-overexpressed hUCB-MSCs (hMSCs-CXCR4) showed a stronger migration capacity toward glioma cells in vitro compared with control MSCs, and also exhibited enhanced migration to glioma cells in an intracranial human malignant glioma xenograft model. These results indicate that SDF-1α/CXCR4 could be involved in recruitment of hUCB-MSCs to glioma cells and that overexpression of CXCR4 may be a useful tool for stem cell-based glioma therapy.

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January 2011
Volume 38 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Park, S.A., Ryu, C.H., Kim, S.M., Lim, J.Y., Park, S.I., Jeong, C.H. ... Jeun, S. (2011). CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas. International Journal of Oncology, 38, 97-103. https://doi.org/10.3892/ijo_00000828
MLA
Park, S. A., Ryu, C. H., Kim, S. M., Lim, J. Y., Park, S. I., Jeong, C. H., Jun, J. A., Oh, J. H., Park, S. H., Oh, W., Jeun, S."CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas". International Journal of Oncology 38.1 (2011): 97-103.
Chicago
Park, S. A., Ryu, C. H., Kim, S. M., Lim, J. Y., Park, S. I., Jeong, C. H., Jun, J. A., Oh, J. H., Park, S. H., Oh, W., Jeun, S."CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas". International Journal of Oncology 38, no. 1 (2011): 97-103. https://doi.org/10.3892/ijo_00000828