Open Access

Epigenetic silencing of RELN in gastric cancer

  • Authors:
    • Osamu Dohi
    • Hisashi Takada
    • Naoki Wakabayashi
    • Kohichiroh Yasui
    • Chouhei Sakakura
    • Shoji Mitsufuji
    • Yuji Naito
    • Masafumi Taniwaki
    • Toshikazu Yoshikawa
  • View Affiliations

  • Published online on: January 1, 2010     https://doi.org/10.3892/ijo_00000478
  • Pages: 85-92
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Abstract

RELN (Reelin) is an extracellular glycoprotein that plays a critical role in neuronal migration. Here we show that the RELN gene is frequently silenced in gastric cancers (GCs) by aberrant promoter hypermethylation. Although RELN was strongly expressed in non-tumor gastric epithelia, its expression was weak, or absent, in GC cell lines and primary GC tumors. Absence of RELN expression significantly correlated with a more advanced stage of GC. Methylation of the RELN promoter was frequently found in GC cell lines and in primary GC tumors. These findings suggest that disruption of the RELN pathway may be involved in gastric carcinogenesis.

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January 2010
Volume 36 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S. ... Yoshikawa, T. (2010). Epigenetic silencing of RELN in gastric cancer. International Journal of Oncology, 36, 85-92. https://doi.org/10.3892/ijo_00000478
MLA
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S., Naito, Y., Taniwaki, M., Yoshikawa, T."Epigenetic silencing of RELN in gastric cancer". International Journal of Oncology 36.1 (2010): 85-92.
Chicago
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S., Naito, Y., Taniwaki, M., Yoshikawa, T."Epigenetic silencing of RELN in gastric cancer". International Journal of Oncology 36, no. 1 (2010): 85-92. https://doi.org/10.3892/ijo_00000478