Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells

  • Authors:
    • Carla Loreto
    • Maria Luisa Carnazza
    • Venera Cardile
    • Massimo Libra
    • Laura Lombardo
    • Grazia Malaponte
    • Giuseppina Martinez
    • Giuseppe Musumeci
    • Veronica Papa
    • Lucio Cocco
  • View Affiliations

  • Published online on: February 1, 2009     https://doi.org/10.3892/ijo_00000160
  • Pages: 371-376
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Abstract

Given the role of phosphoinositide-specific phospholipase C (PLC) isozymes in the control of cell growth and differentiation we were prompted to analyze the expression of some of these PLC in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells. The effects of several fluoro-edenite fibers were compared with those of tremolite, a member of the calcic amphibole group of asbestos that originates from Calabria (Italy), and crocidolite, that, due to its high toxicity, is one of the most studied asbestos amphiboles. Our data show an increased expression of both PLC β1 and PLC γ1 in A549 cells treated with asbestos-like fibers, hinting at a role of PLC signalling in those cancerous cells.

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February 2009
Volume 34 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Loreto, C., Carnazza, M.L., Cardile, V., Libra, M., Lombardo, L., Malaponte, G. ... Cocco, L. (2009). Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells. International Journal of Oncology, 34, 371-376. https://doi.org/10.3892/ijo_00000160
MLA
Loreto, C., Carnazza, M. L., Cardile, V., Libra, M., Lombardo, L., Malaponte, G., Martinez, G., Musumeci, G., Papa, V., Cocco, L."Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells". International Journal of Oncology 34.2 (2009): 371-376.
Chicago
Loreto, C., Carnazza, M. L., Cardile, V., Libra, M., Lombardo, L., Malaponte, G., Martinez, G., Musumeci, G., Papa, V., Cocco, L."Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells". International Journal of Oncology 34, no. 2 (2009): 371-376. https://doi.org/10.3892/ijo_00000160