HLA class I antigens are possible prognostic factors in hepatocellular carcinoma

  • Authors:
    • M Nishibe
    • Y Une
    • M Kobayashi
    • Y Kuramitsu
    • M Hosokawa
    • J Uchino
  • View Affiliations

  • Published online on: June 1, 1996     https://doi.org/10.3892/ijo.8.6.1243
  • Pages: 1243-1247
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Abstract

Thirty patients who underwent hepatectomy for the treatment of hepatocellular carcinoma (HCC) were examined for expression of HLA class I antigens on HCC cells by flow cytometry. The expression was found significantly lower in cases of stage IV compared with those of stage I or stage II (p<0.05), and in cases of intrahepatic metastases compared with those without metastases (p<0.001). In cases of non-curative hepatectomy, the expression of HLA class I antigens was lower compared with those treated by curative resection. Postoperative cumulative disease-free survival rates were well correlated with the expression rate of HLA class I antigens (p<0.05). Expression of HLA class I antigens on HCC may indicate low malignancy and better prognosis.

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June 1996
Volume 8 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Nishibe, M., Une, Y., Kobayashi, M., Kuramitsu, Y., Hosokawa, M., & Uchino, J. (1996). HLA class I antigens are possible prognostic factors in hepatocellular carcinoma. International Journal of Oncology, 8, 1243-1247. https://doi.org/10.3892/ijo.8.6.1243
MLA
Nishibe, M., Une, Y., Kobayashi, M., Kuramitsu, Y., Hosokawa, M., Uchino, J."HLA class I antigens are possible prognostic factors in hepatocellular carcinoma". International Journal of Oncology 8.6 (1996): 1243-1247.
Chicago
Nishibe, M., Une, Y., Kobayashi, M., Kuramitsu, Y., Hosokawa, M., Uchino, J."HLA class I antigens are possible prognostic factors in hepatocellular carcinoma". International Journal of Oncology 8, no. 6 (1996): 1243-1247. https://doi.org/10.3892/ijo.8.6.1243