Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells

  • Authors:
    • P Arvind
    • L Qiao
    • E Papavassiliou
    • E Goldin
    • M Koutsos
    • B Rigas
  • View Affiliations

  • Published online on: June 1, 1996     https://doi.org/10.3892/ijo.8.6.1207
  • Pages: 1207-1211
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Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of colon cancer. The underexpression of HLA antigens during colon cancer development is suspected to be a mechanism by which malignant cells escape immune surveillance. We examined whether NSAIDs affect the expression of HLA-DR in HT29 human colon adenocarcinoma cells, which do not express HLA-DR. Aspirin, indomethacin and sulindac induced several-fold the expression of HLA-DR in these cells in a concentration- and time-dependent manner. Aspirin increased HLA-DR alpha steady-state mRNA levels and HLA-DR alpha gene transcription rate. These findings raise the possibility that such a mechanism may be operative in vivo.

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June 1996
Volume 8 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Arvind, P., Qiao, L., Papavassiliou, E., Goldin, E., Koutsos, M., & Rigas, B. (1996). Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells. International Journal of Oncology, 8, 1207-1211. https://doi.org/10.3892/ijo.8.6.1207
MLA
Arvind, P., Qiao, L., Papavassiliou, E., Goldin, E., Koutsos, M., Rigas, B."Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells". International Journal of Oncology 8.6 (1996): 1207-1211.
Chicago
Arvind, P., Qiao, L., Papavassiliou, E., Goldin, E., Koutsos, M., Rigas, B."Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells". International Journal of Oncology 8, no. 6 (1996): 1207-1211. https://doi.org/10.3892/ijo.8.6.1207