Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells
- P Arvind
- L Qiao
- E Papavassiliou
- E Goldin
- M Koutsos
- B Rigas
Affiliations: CORNELL UNIV,COLL MED,DEPT MED,NEW YORK,NY 10021.
- Published online on: June 1, 1996 https://doi.org/10.3892/ijo.8.6.1207
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Nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of colon cancer. The underexpression of HLA antigens during colon cancer development is suspected to be a mechanism by which malignant cells escape immune surveillance. We examined whether NSAIDs affect the expression of HLA-DR in HT29 human colon adenocarcinoma cells, which do not express HLA-DR. Aspirin, indomethacin and sulindac induced several-fold the expression of HLA-DR in these cells in a concentration- and time-dependent manner. Aspirin increased HLA-DR alpha steady-state mRNA levels and HLA-DR alpha gene transcription rate. These findings raise the possibility that such a mechanism may be operative in vivo.