Fluted serum relating to growth of both hepatocyte and hepatocellular carcinoma cells
- T Namieno
- N Sato
- J Uchino
- K Yamashita
- M Hosokawa
Affiliations: HOKKAIDO UNIV,SCH MED,PATHOL LAB,INST CANC,SAPPORO,HOKKAIDO 060,JAPAN.
- Published online on: June 1, 1996 https://doi.org/10.3892/ijo.8.6.1195
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This study was undertaken to investigate a humoral substance contributing to both primary hepatocytes and hepatocellular carcinoma (HCC) cells in the primitive form. Peripheral blood from rat, 24 h after partial hepatectomy (PH) or sham-operation, was eluted into 50 fractions using an HPLC, and each fraction was bio-assayed. In vivo relationship between PH and tumor growth was also evaluated. Only one, approximately 100 kDa, of the 50 fractions from PH rat stimulated the growth of both types of cell, and the time-lag between PH and HCC injection also correlated significantly with tumor appearance and growth. Serum in PH rats contains certain humoral stimulator(s) contributing to growth of both hepatocyte and HCC cells.