An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C) shows more aggressive biologic behavior than an alpha-fetoprotein-non-producing cell line

  • Authors:
    • M Maruiwa
    • H Yano
    • K Fukuda
    • S Ogasawara
    • T Hisaka
    • R Yamaguchi
    • M Kojiro
  • View Affiliations

  • Published online on: June 1, 1996     https://doi.org/10.3892/ijo.8.6.1179
  • Pages: 1179-1188
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Abstract

We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and carbohydrate antigen 19-9, as well as 7 serum proteins, including albumin and C-reactive protein. KMG-C showed more malignant biological behavior than an AFP-nonproducing GBC cell line, KMG-A, established originally from the tumor of the same patient; KMG-C had a shorter doubling time, higher tumorigenicity, and an aneuploid DNA index. Our results suggest that AFP-producing GBC cells may have more malignant biological characteristics than AFP-non-producing GBC cells in GBCs having both of these components.

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June 1996
Volume 8 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Maruiwa, M., Yano, H., Fukuda, K., Ogasawara, S., Hisaka, T., Yamaguchi, R., & Kojiro, M. (1996). An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C) shows more aggressive biologic behavior than an alpha-fetoprotein-non-producing cell line. International Journal of Oncology, 8, 1179-1188. https://doi.org/10.3892/ijo.8.6.1179
MLA
Maruiwa, M., Yano, H., Fukuda, K., Ogasawara, S., Hisaka, T., Yamaguchi, R., Kojiro, M."An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C) shows more aggressive biologic behavior than an alpha-fetoprotein-non-producing cell line". International Journal of Oncology 8.6 (1996): 1179-1188.
Chicago
Maruiwa, M., Yano, H., Fukuda, K., Ogasawara, S., Hisaka, T., Yamaguchi, R., Kojiro, M."An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C) shows more aggressive biologic behavior than an alpha-fetoprotein-non-producing cell line". International Journal of Oncology 8, no. 6 (1996): 1179-1188. https://doi.org/10.3892/ijo.8.6.1179