Endometrial hyperplasia and endometrial carcinoma induce a vasoproliferative response in the chick embryo chorioallantoic membrane

  • Authors:
    • D Ribatti
    • A Vacca
    • G Gasparini
    • G Loverro
    • G DiVagno
    • M Iurlaro
    • C Lotesoriere
    • L Roncali
    • L Selvaggi
  • View Affiliations

  • Published online on: June 1, 1996     https://doi.org/10.3892/ijo.8.6.1149
  • Pages: 1149-1153
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Abstract

Ten specimens of endometrial adenocarcinoma, of endometrial hyperplasia and uterine prolapse (the latter used as controls), respectively, were grafted onto the chick embryo chorioallantoic membrane (CAM) to investigate their angiogenic activity. The vasoproliferative response was assessed four days after grafting on histologic sections by a planimetric point-count method. Microvessel counts in the CAM area under and around the implants were significantly higher in endometrial adenocarcinoma than in endometrial hyperplasia and in the latter over the controls. These findings show that endometrial hyperplasia and endometrial adenocarcinoma are angiogenic. These results confirm previous observation that angiogenic activity is both a marker of the passage between preneoplastic to neoplastic status and an event that influences tumour progression.

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June 1996
Volume 8 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Ribatti, D., Vacca, A., Gasparini, G., Loverro, G., DiVagno, G., Iurlaro, M. ... Selvaggi, L. (1996). Endometrial hyperplasia and endometrial carcinoma induce a vasoproliferative response in the chick embryo chorioallantoic membrane. International Journal of Oncology, 8, 1149-1153. https://doi.org/10.3892/ijo.8.6.1149
MLA
Ribatti, D., Vacca, A., Gasparini, G., Loverro, G., DiVagno, G., Iurlaro, M., Lotesoriere, C., Roncali, L., Selvaggi, L."Endometrial hyperplasia and endometrial carcinoma induce a vasoproliferative response in the chick embryo chorioallantoic membrane". International Journal of Oncology 8.6 (1996): 1149-1153.
Chicago
Ribatti, D., Vacca, A., Gasparini, G., Loverro, G., DiVagno, G., Iurlaro, M., Lotesoriere, C., Roncali, L., Selvaggi, L."Endometrial hyperplasia and endometrial carcinoma induce a vasoproliferative response in the chick embryo chorioallantoic membrane". International Journal of Oncology 8, no. 6 (1996): 1149-1153. https://doi.org/10.3892/ijo.8.6.1149