Endometrial hyperplasia and endometrial carcinoma induce a vasoproliferative response in the chick embryo chorioallantoic membrane
- D Ribatti
- A Vacca
- G Gasparini
- G Loverro
- G DiVagno
- M Iurlaro
- C Lotesoriere
- L Roncali
- L Selvaggi
Affiliations: UNIV BARI,SCH MED,DEPT BIOMED SCI & HUMAN ONCOL,I-70124 BARI,ITALY. ST BORTOLO HOSP,DEPT ONCOL,I-36100 VICENZA,ITALY. UNIV BARI,SCH MED,INST OBSTET & GYNECOL,I-70124 BARI,ITALY.
- Published online on: June 1, 1996 https://doi.org/10.3892/ijo.8.6.1149
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Ten specimens of endometrial adenocarcinoma, of endometrial hyperplasia and uterine prolapse (the latter used as controls), respectively, were grafted onto the chick embryo chorioallantoic membrane (CAM) to investigate their angiogenic activity. The vasoproliferative response was assessed four days after grafting on histologic sections by a planimetric point-count method. Microvessel counts in the CAM area under and around the implants were significantly higher in endometrial adenocarcinoma than in endometrial hyperplasia and in the latter over the controls. These findings show that endometrial hyperplasia and endometrial adenocarcinoma are angiogenic. These results confirm previous observation that angiogenic activity is both a marker of the passage between preneoplastic to neoplastic status and an event that influences tumour progression.