Detection of micro invasion during progression in preneoplastic human breast xenograft model

  • Authors:
    • L Tait
    • P Dawson
    • F Miller
  • View Affiliations

  • Published online on: June 1, 1996     https://doi.org/10.3892/ijo.8.6.1113
  • Pages: 1113-1117
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Abstract

Xenografted MCF10AT cell lines develop regions resembling human proliferative breast disease including atypical hyperplasia and carcinoma in situ (CIS). The lesions are truly preneoplastic because progression to invasive carcinoma occurs. Sporadic, stepwise progression produces xenografts in which relatively normal ducts, hyperplastic ducts, CIS, and invasive carcinoma may coexist. However, early invasive events are difficult to discern. A silver stain that identifies basement membrane due to the content of glycoprotein was used to define areas of invasiveness. The method confirms the progressive nature of the xenograft model, identifies micro invasive fronts, and allows definitive classification of lesion components.

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June 1996
Volume 8 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Tait, L., Dawson, P., & Miller, F. (1996). Detection of micro invasion during progression in preneoplastic human breast xenograft model. International Journal of Oncology, 8, 1113-1117. https://doi.org/10.3892/ijo.8.6.1113
MLA
Tait, L., Dawson, P., Miller, F."Detection of micro invasion during progression in preneoplastic human breast xenograft model". International Journal of Oncology 8.6 (1996): 1113-1117.
Chicago
Tait, L., Dawson, P., Miller, F."Detection of micro invasion during progression in preneoplastic human breast xenograft model". International Journal of Oncology 8, no. 6 (1996): 1113-1117. https://doi.org/10.3892/ijo.8.6.1113