P53, Bcl-2 expression and cell proliferation in benign breast lesions

  • Authors:
    • L DiMartino
    • E Benini
    • A Faranda
    • B DeMontis
    • G Murenu
    • A Ferreli
    • M Daidone
    • R Silvestrtni
  • View Affiliations

  • Published online on: June 1, 1996     https://doi.org/10.3892/ijo.8.6.1053
  • Pages: 1053-1057
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Abstract

The role of proliferation-related markers on breast cancer pathogenesis has been only occasionally investigated. The immunocytochemical expression of P53 and Bcl-2 (using PAb1801 and anti-bcl-2 monoclonal antibodies) and cell proliferation (evaluated as the H-3-thymidine labeling index [H-3-dT LI]) were determined on 62 benign breast lesions at different risk. Accumulation of the P53 protein was never observed; Bcl-2 was detected in 50% of cases and it was unrelated to biologic and clinicopathologic features. Median H-3-dT LI was about three times lower than that observed on large series of invasive breast cancer. It was only slightly higher in lesions from patients younger than 35 years or with a positive family history than in those under 35 or with a negative family history and appeared unrelated to histology or risk classification. Such findings indicate that the investigated biomarkers fail to identify women at increased risk for breast cancer.

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June 1996
Volume 8 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
DiMartino, L., Benini, E., Faranda, A., DeMontis, B., Murenu, G., Ferreli, A. ... Silvestrtni, R. (1996). P53, Bcl-2 expression and cell proliferation in benign breast lesions. International Journal of Oncology, 8, 1053-1057. https://doi.org/10.3892/ijo.8.6.1053
MLA
DiMartino, L., Benini, E., Faranda, A., DeMontis, B., Murenu, G., Ferreli, A., Daidone, M., Silvestrtni, R."P53, Bcl-2 expression and cell proliferation in benign breast lesions". International Journal of Oncology 8.6 (1996): 1053-1057.
Chicago
DiMartino, L., Benini, E., Faranda, A., DeMontis, B., Murenu, G., Ferreli, A., Daidone, M., Silvestrtni, R."P53, Bcl-2 expression and cell proliferation in benign breast lesions". International Journal of Oncology 8, no. 6 (1996): 1053-1057. https://doi.org/10.3892/ijo.8.6.1053