Stereotactic radiosurgery for metastatic brain tumors

  • Authors:
    • M Chamberlain
    • P Kormanik
    • D Barba
    • B Fuller
    • D Smith
    • W Shea
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/ijo.8.3.617
  • Pages: 617-624
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Abstract

We report on a prospective phase TI study utilizing stereotactic radiosurgery for patients with intracranial parenchymal metastases. Fifty patients ranging in age from 38 to 77 years with 1 to 3 intraparenchymal brain metastases were treated with stereotactic radiosurgery either immediately following whole brain radiotherapy or at the time of intracranial disease progression following failure of whole brain radiotherapy. Twenty patients treated with adjuvant therapy received a median radiosurgical dose of 20 Gy. Thirty patients treated with salvage therapy received a median radiosurgical dose of 20 Gy. No immediate neurotoxicity was seen following radiosurgery however, 4 patients (8%) developed symptomatic radiation necrosis. Median survival was 6.5 and 6.0 months for patients treated with adjuvant and salvage radiosurgery respectively. In patients with oligometastatic brain metastases manifesting intracranial disease progression after whole brain radiotherapy, salvage radiotherapy appears to offer improved palliation when compared to retreatment with whole brain radiotherapy. The results of patients treated with up-front adjuvant radiosurgery when compared to historical controls treated with whole brain radiotherapy only are less clear as to benefit and require a phase III study before definitive recommendations can be made.

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March 1996
Volume 8 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., & Shea, W. (1996). Stereotactic radiosurgery for metastatic brain tumors. International Journal of Oncology, 8, 617-624. https://doi.org/10.3892/ijo.8.3.617
MLA
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., Shea, W."Stereotactic radiosurgery for metastatic brain tumors". International Journal of Oncology 8.3 (1996): 617-624.
Chicago
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., Shea, W."Stereotactic radiosurgery for metastatic brain tumors". International Journal of Oncology 8, no. 3 (1996): 617-624. https://doi.org/10.3892/ijo.8.3.617