Differentiation of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus is accompanied by nuclear accumulation of the tumor suppressor p53

  • Authors:
    • F Borellini
    • R Glazer
    • L Kopelovich
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/ijo.8.3.609
  • Pages: 609-615
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Abstract

Snyder-Theilen feline sarcoma virus (ST:FeSV)-transduced human fibroblasts differentiate into tissue macrophages with many of the properties of normal macrophages. These cells express high levels of the gag-fes tyrosine kinase fusion protein, p85(v-fes), and exhibit an elevated level of tyrosine phosphorylation. Expression of the macrophage phenotype is accompanied by increased levels of DNA-binding activity and nuclear accumulation of wild-type p53. The DNA-binding activity of the transcription factors Egr-1, CREB and Sp1, which are known to be involved in cell differentiation, is also increased in ST:FeSV-induced macrophages. These observations suggest that v-fes can activate signal transduction pathways normally involved in macrophage differentiation, and that transcription factors such as p53, further facilitate v-fes-induced terminal differentiation.

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March 1996
Volume 8 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Borellini, F., Glazer, R., & Kopelovich, L. (1996). Differentiation of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus is accompanied by nuclear accumulation of the tumor suppressor p53. International Journal of Oncology, 8, 609-615. https://doi.org/10.3892/ijo.8.3.609
MLA
Borellini, F., Glazer, R., Kopelovich, L."Differentiation of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus is accompanied by nuclear accumulation of the tumor suppressor p53". International Journal of Oncology 8.3 (1996): 609-615.
Chicago
Borellini, F., Glazer, R., Kopelovich, L."Differentiation of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus is accompanied by nuclear accumulation of the tumor suppressor p53". International Journal of Oncology 8, no. 3 (1996): 609-615. https://doi.org/10.3892/ijo.8.3.609