Correlation between overexpression of c-met gene and the progression of gastric cancer

  • Authors:
    • Y Yonemura
    • M Kaji
    • Y Hirono
    • S Fushida
    • K Tsugawa
    • T Fujimura
    • I Miyazaki
    • S Harada
    • H Yamamoto
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/ijo.8.3.555
  • Pages: 555-560
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Abstract

The c-met oncogene encodes a receptor of hepatocyte growth factor (HGF), which has both mitogenic and motogenic activities. We have studied the c-met gene expression in gastric cancer by immunohistochemical method using an antibody specific to the c-met beta-chain. c-met immunoreactivity was preferentially localize on the cell membrane, and 55 (43%) of 127 primary gastric cancers showed c-met immunoreactivity. Strong correlation was found between c-met expression in large tumors, lymph node involvement, serosal invasion, as well as peritoneal dissemination. Furthermore, c-met positive tumors had a tendency to metastasize to more distant lymph node sites. Regarding the macroscopic type, Borrmann type 4 gastric cancer showed the highest incidence (12/16, 76%) of positive c-met expression. Patients with c-met positive tumor ran a significantly poorer prognosis than those with c-met negative one. These results indicate that the c-met protein participates in the progression and invasion of stomach cancer, and that c-met tissue status is a useful biological marker in gastric cancer.

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March 1996
Volume 8 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yonemura, Y., Kaji, M., Hirono, Y., Fushida, S., Tsugawa, K., Fujimura, T. ... Yamamoto, H. (1996). Correlation between overexpression of c-met gene and the progression of gastric cancer. International Journal of Oncology, 8, 555-560. https://doi.org/10.3892/ijo.8.3.555
MLA
Yonemura, Y., Kaji, M., Hirono, Y., Fushida, S., Tsugawa, K., Fujimura, T., Miyazaki, I., Harada, S., Yamamoto, H."Correlation between overexpression of c-met gene and the progression of gastric cancer". International Journal of Oncology 8.3 (1996): 555-560.
Chicago
Yonemura, Y., Kaji, M., Hirono, Y., Fushida, S., Tsugawa, K., Fujimura, T., Miyazaki, I., Harada, S., Yamamoto, H."Correlation between overexpression of c-met gene and the progression of gastric cancer". International Journal of Oncology 8, no. 3 (1996): 555-560. https://doi.org/10.3892/ijo.8.3.555