Antibody-dependent cytotoxic activity on human cancer cells expressing UK 114 tumor membrane antigen

  • Authors:
    • A Bartorelli
    • B Bussolati
    • M Millesimo
    • P Gugliotta
    • G Bussolati
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/ijo.8.3.543
  • Pages: 543-548
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Abstract

The monoclonal antibody (P-3 mAb) and the rabbit immune sera (RIS) recognizing a 14 kDa perchloric acid soluble protein extracted from goat liver (UK 114), locate this antigen on the cell membrane of several human cancer cell lines. UK 114-positive cells (e.g. HT 29 and KATO VI cells) undergo antibody-dependent cytolysis bl vitro. In nu/nu mice bearing xenografted HT 29 cells, tumor growth was markedly impaired by peri-tumoral injection of anti-UK 114 antibodies. These experiments suggest that human tumors expressing UK 114 over the cell membrane may undergo antibody-mediated cytolysis and growth control.

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March 1996
Volume 8 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Bartorelli, A., Bussolati, B., Millesimo, M., Gugliotta, P., & Bussolati, G. (1996). Antibody-dependent cytotoxic activity on human cancer cells expressing UK 114 tumor membrane antigen. International Journal of Oncology, 8, 543-548. https://doi.org/10.3892/ijo.8.3.543
MLA
Bartorelli, A., Bussolati, B., Millesimo, M., Gugliotta, P., Bussolati, G."Antibody-dependent cytotoxic activity on human cancer cells expressing UK 114 tumor membrane antigen". International Journal of Oncology 8.3 (1996): 543-548.
Chicago
Bartorelli, A., Bussolati, B., Millesimo, M., Gugliotta, P., Bussolati, G."Antibody-dependent cytotoxic activity on human cancer cells expressing UK 114 tumor membrane antigen". International Journal of Oncology 8, no. 3 (1996): 543-548. https://doi.org/10.3892/ijo.8.3.543