Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue

  • Authors:
    • G Stammler
    • R Koomagi
    • J Mattern
    • M Volm
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/ijo.8.3.537
  • Pages: 537-542
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Abstract

Drug resistance related proteins P-glycoprotein (P170), multidrug resistance associated protein (MRP), glutathione S-transferase-pi (GST-pi), glutathione peroxidase (GPX), topoisomerase II (Topo II), thymidylate synthase (TS), O-6-methylguanine-DNA-methyltransferase (MGMT), the heat shock proteins HSP27 and HSP70 and the protooncogenes Fos, Jun and EGFR were investigated in human lung carcinomas and matched normal tissues. We found that the mRNA expression of Topo II and TS were elevated in tumor tissue versus corresponding normal tissue. Additionally Topo II and TS correlated with the proliferating activity determined by expression of histone 3. P170, MRP, HSP70 and also EGFR mRNA were elevated in some tumor probes, but not GST-pi, GPX, MGMT and HSP27 mRNA. Additionally, we determined various values of Fos and Jun mRNA expression but there was no uniform pattern. The finding that some proteins were abnormally expressed in lung tumors compared to the adjacent normal tissue is an important finding for further investigations on the development of individualized chemotherapy but more samples should be examined to extend these observations.

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March 1996
Volume 8 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Stammler, G., Koomagi, R., Mattern, J., & Volm, M. (1996). Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue. International Journal of Oncology, 8, 537-542. https://doi.org/10.3892/ijo.8.3.537
MLA
Stammler, G., Koomagi, R., Mattern, J., Volm, M."Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue". International Journal of Oncology 8.3 (1996): 537-542.
Chicago
Stammler, G., Koomagi, R., Mattern, J., Volm, M."Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue". International Journal of Oncology 8, no. 3 (1996): 537-542. https://doi.org/10.3892/ijo.8.3.537