Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha can mediate macrophage infiltration in gliomas

  • Authors:
    • K Yoshizato
    • J Kuratsu
    • H Takeshima
    • T Nishi
    • T Yoshimura
    • Y Ushio
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/ijo.8.3.493
  • Pages: 493-497
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Abstract

We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that MCP-1 expression was highly induced by tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta. The intra-tumoral injection of TNF alpha in rat glioma model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection and induced macrophage infiltration into tumor tissue. The injection of TNF alpha into post-operative tumor cavity of human malignant glioma also increased the concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These data, together with the previous finding that the growth of transplanted MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, suggest that injection of TNF alpha inhibits turner growth via the induction of MCP-1 expression.

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March 1996
Volume 8 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yoshizato, K., Kuratsu, J., Takeshima, H., Nishi, T., Yoshimura, T., & Ushio, Y. (1996). Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha can mediate macrophage infiltration in gliomas. International Journal of Oncology, 8, 493-497. https://doi.org/10.3892/ijo.8.3.493
MLA
Yoshizato, K., Kuratsu, J., Takeshima, H., Nishi, T., Yoshimura, T., Ushio, Y."Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha can mediate macrophage infiltration in gliomas". International Journal of Oncology 8.3 (1996): 493-497.
Chicago
Yoshizato, K., Kuratsu, J., Takeshima, H., Nishi, T., Yoshimura, T., Ushio, Y."Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha can mediate macrophage infiltration in gliomas". International Journal of Oncology 8, no. 3 (1996): 493-497. https://doi.org/10.3892/ijo.8.3.493