IL-2 RECEPTOR EXPRESSION AND KI-67 FLOW CYTOMETRIC ANALYSIS IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA
- A AYDIN
- AK ELNAGGAR
- LE ROBERTSON
- MJ KEATING
- YO HUH
Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,DIV PATHOL,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT LAB MED,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,HOUSTON,TX 77030.
- Published online on: December 1, 1995 https://doi.org/10.3892/ijo.7.6.1433
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Chronic lymphocytic leukemia (CLL) is typically an indolent lympho-proliferative disorder. Its clinical course is notable for marked heterogeneity, but in a subset of patients, the disease pursues a relatively rapid clinical course. To identify patients that may have aggressive disease, the growth fraction as determined by Ki-67 proliferation marker, DNA and RNA content, and IL-2 receptor expression were determined in 46 patients with CLL by flow cytometry. Our results indicate a significant statistical correlation between Ki-67 positivity and IL-2 expression in B-CLL cells. No correlation between the proliferative activity or RNA content and IL-2 expression was found. Our data indicate that measurement of both IL-2 receptor and Ki-67 expression in B-CLL can identify a subset of patients with a high risk of rapid clinical progression.