IL-2 RECEPTOR EXPRESSION AND KI-67 FLOW CYTOMETRIC ANALYSIS IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA

  • Authors:
    • A AYDIN
    • AK ELNAGGAR
    • LE ROBERTSON
    • MJ KEATING
    • YO HUH
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1433
  • Pages: 1433-1436
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Abstract

Chronic lymphocytic leukemia (CLL) is typically an indolent lympho-proliferative disorder. Its clinical course is notable for marked heterogeneity, but in a subset of patients, the disease pursues a relatively rapid clinical course. To identify patients that may have aggressive disease, the growth fraction as determined by Ki-67 proliferation marker, DNA and RNA content, and IL-2 receptor expression were determined in 46 patients with CLL by flow cytometry. Our results indicate a significant statistical correlation between Ki-67 positivity and IL-2 expression in B-CLL cells. No correlation between the proliferative activity or RNA content and IL-2 expression was found. Our data indicate that measurement of both IL-2 receptor and Ki-67 expression in B-CLL can identify a subset of patients with a high risk of rapid clinical progression.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
AYDIN, A., ELNAGGAR, A., ROBERTSON, L., KEATING, M., & HUH, Y. (1995). IL-2 RECEPTOR EXPRESSION AND KI-67 FLOW CYTOMETRIC ANALYSIS IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA. International Journal of Oncology, 7, 1433-1436. https://doi.org/10.3892/ijo.7.6.1433
MLA
AYDIN, A., ELNAGGAR, A., ROBERTSON, L., KEATING, M., HUH, Y."IL-2 RECEPTOR EXPRESSION AND KI-67 FLOW CYTOMETRIC ANALYSIS IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA". International Journal of Oncology 7.6 (1995): 1433-1436.
Chicago
AYDIN, A., ELNAGGAR, A., ROBERTSON, L., KEATING, M., HUH, Y."IL-2 RECEPTOR EXPRESSION AND KI-67 FLOW CYTOMETRIC ANALYSIS IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA". International Journal of Oncology 7, no. 6 (1995): 1433-1436. https://doi.org/10.3892/ijo.7.6.1433