ON THE RELATIONSHIP OF ATP DEPLETION TO CHEMOTHERAPEUTICALLY-INDUCED TUMOR-REGRESSION

  • Authors:
    • JR COLOFIORE
    • RL STOLFI
    • LD NORD
    • DS MARTIN
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1401
  • Pages: 1401-1404
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Abstract

A positive correlation was found between increasing ATP depletion and enhanced tumor-regressing activity by combining PMA, a three drug combination (PALA, MMPR+6-AN), with FUra, or Adria, or FUra+Adria. For example, at 48 h post treatment, ATP was 68% of saline controls with a 10% tumor regression rate (PMA); ATP was 55% with a 60% regression rate (PMA+FUra); ATP was 54% with an 80% regression rate (PMA+Adria); and ATP was 30% with a;100% regression rate (PMA+FUra+Adria). The results give support to the suggestion that ATP depletion may be a significant factor in the production of chemotherapeutically-induced apoptosis.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
COLOFIORE, J., STOLFI, R., NORD, L., & MARTIN, D. (1995). ON THE RELATIONSHIP OF ATP DEPLETION TO CHEMOTHERAPEUTICALLY-INDUCED TUMOR-REGRESSION. International Journal of Oncology, 7, 1401-1404. https://doi.org/10.3892/ijo.7.6.1401
MLA
COLOFIORE, J., STOLFI, R., NORD, L., MARTIN, D."ON THE RELATIONSHIP OF ATP DEPLETION TO CHEMOTHERAPEUTICALLY-INDUCED TUMOR-REGRESSION". International Journal of Oncology 7.6 (1995): 1401-1404.
Chicago
COLOFIORE, J., STOLFI, R., NORD, L., MARTIN, D."ON THE RELATIONSHIP OF ATP DEPLETION TO CHEMOTHERAPEUTICALLY-INDUCED TUMOR-REGRESSION". International Journal of Oncology 7, no. 6 (1995): 1401-1404. https://doi.org/10.3892/ijo.7.6.1401