ON THE RELATIONSHIP OF ATP DEPLETION TO CHEMOTHERAPEUTICALLY-INDUCED TUMOR-REGRESSION
- JR COLOFIORE
- RL STOLFI
- LD NORD
- DS MARTIN
Affiliations: MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. CATHOLIC MED CTR,WOODHAVEN,NY 11421.
- Published online on: December 1, 1995 https://doi.org/10.3892/ijo.7.6.1401
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A positive correlation was found between increasing ATP depletion and enhanced tumor-regressing activity by combining PMA, a three drug combination (PALA, MMPR+6-AN), with FUra, or Adria, or FUra+Adria. For example, at 48 h post treatment, ATP was 68% of saline controls with a 10% tumor regression rate (PMA); ATP was 55% with a 60% regression rate (PMA+FUra); ATP was 54% with an 80% regression rate (PMA+Adria); and ATP was 30% with a;100% regression rate (PMA+FUra+Adria). The results give support to the suggestion that ATP depletion may be a significant factor in the production of chemotherapeutically-induced apoptosis.