BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE

  • Authors:
    • K AOGI
    • M NISHIYAMA
    • S SAEKI
    • N HIRABAYASHI
    • T TOGE
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1395
  • Pages: 1395-1399
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Abstract

A new isoprenoid derivative, N-1379, was evaluated as a modulating agent of doxorubicin (DOX)-induced anticancer efficacy. The level of plasma transmembrane potential, measured using DiOC6(3), correlated with cellular sensitivity to DOX in K562 myelogenous leukemia, SH101 stomach, and PH101 pancreatic cancer cells. Non-toxic N-1379 increased the cellular transmembrane potential and DOX efficacy for three cell lines. The modulation of membrane function was accompanied by increases of DOX accumulation and S/G(2)M phase population in these cells. Overexpression of a 170 kD plasma membrane glycoprotein (GP-170) was not observed in any cells examined. We suggest therefore that interaction between electronegative transmembrane potential and positive charge of DOX may be linked to intracellular DOX accumulation. N-1379 may augment DOX efficacy through its increasing effect on plasma membrane potential independently of GP-170 overexpression.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., & TOGE, T. (1995). BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE. International Journal of Oncology, 7, 1395-1399. https://doi.org/10.3892/ijo.7.6.1395
MLA
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., TOGE, T."BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE". International Journal of Oncology 7.6 (1995): 1395-1399.
Chicago
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., TOGE, T."BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE". International Journal of Oncology 7, no. 6 (1995): 1395-1399. https://doi.org/10.3892/ijo.7.6.1395