TRANSFORMATION OF RAT FIBROBLASTS BY TGF-BETA - RESTRICTION TO A MINOR SUBPOPULATION, RATHER THAN A RARE EVENT

  • Authors:
    • C DICHGANS
    • P HOFLER
    • G BAUER
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1367
  • Pages: 1367-1371
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Abstract

TGF-beta has the ability to transform rat fibroblasts, but it also induces neigbouring normal cells to eliminate newly arizing transformed cells. Therefore, the transforming effect of TGF-beta can only be demonstrated when it is added to rat fibroblasts sparsely seeded in soft agar. Combination of monolayer and soft agar cultures revealed the unexpected result that transformation of rat fibroblasts by TGF-beta acts on a distinct subpopulation rather than reaching the total population. As a consequence, the comparison of transformed cells with the parental untransformed random cell population is not adequate to define alterations acquired during the transformation process.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
DICHGANS, C., HOFLER, P., & BAUER, G. (1995). TRANSFORMATION OF RAT FIBROBLASTS BY TGF-BETA - RESTRICTION TO A MINOR SUBPOPULATION, RATHER THAN A RARE EVENT. International Journal of Oncology, 7, 1367-1371. https://doi.org/10.3892/ijo.7.6.1367
MLA
DICHGANS, C., HOFLER, P., BAUER, G."TRANSFORMATION OF RAT FIBROBLASTS BY TGF-BETA - RESTRICTION TO A MINOR SUBPOPULATION, RATHER THAN A RARE EVENT". International Journal of Oncology 7.6 (1995): 1367-1371.
Chicago
DICHGANS, C., HOFLER, P., BAUER, G."TRANSFORMATION OF RAT FIBROBLASTS BY TGF-BETA - RESTRICTION TO A MINOR SUBPOPULATION, RATHER THAN A RARE EVENT". International Journal of Oncology 7, no. 6 (1995): 1367-1371. https://doi.org/10.3892/ijo.7.6.1367